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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F10%3A00002300%21RIV11-MO0-G44_____
rdf:type
n17:Vysledek skos:Concept
dcterms:description
A new tacrine based cholinesterase inhibitor, N-(bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine (1), was designed and synthesized to interact with specific regions of human acetylcholinesterase and human butyrylcholinesterase. Its inhibitory ability towards cholinesterases was determined and compared to tacrine (THA) and 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine (7-MEOTA). The assessment of IC50 values revealed 1 as a weak inhibitor of both tested enzymes. A new tacrine based cholinesterase inhibitor, N-(bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine (1), was designed and synthesized to interact with specific regions of human acetylcholinesterase and human butyrylcholinesterase. Its inhibitory ability towards cholinesterases was determined and compared to tacrine (THA) and 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine (7-MEOTA). The assessment of IC50 values revealed 1 as a weak inhibitor of both tested enzymes.
dcterms:title
Synthesis and in vitro evaluation of N-(bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment Synthesis and in vitro evaluation of N-(bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment
skos:prefLabel
Synthesis and in vitro evaluation of N-(bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment Synthesis and in vitro evaluation of N-(bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment
skos:notation
RIV/60162694:G44__/10:00002300!RIV11-MO0-G44_____
n4:aktivita
n6:S n6:P n6:Z
n4:aktivity
P(OVUOFVZ200805), S, Z(MSM0021620822)
n4:cisloPeriodika
12
n4:dodaniDat
n8:2011
n4:domaciTvurceVysledku
n9:1022989 n9:6469922 n9:6306888 n9:4185137
n4:druhVysledku
n11:J
n4:duvernostUdaju
n14:S
n4:entitaPredkladatele
n13:predkladatel
n4:idSjednocenehoVysledku
291483
n4:idVysledku
RIV/60162694:G44__/10:00002300
n4:jazykVysledku
n18:eng
n4:klicovaSlova
tacrine; acetylcholinesterase; butyrylcholinesterase; 7-MEOTA; inhibition; Alzheimer disease
n4:klicoveSlovo
n16:butyrylcholinesterase n16:Alzheimer%20disease n16:tacrine n16:acetylcholinesterase n16:inhibition n16:7-MEOTA
n4:kodStatuVydavatele
CH - Švýcarská konfederace
n4:kontrolniKodProRIV
[E246040EDCAE]
n4:nazevZdroje
Molecules
n4:obor
n15:FR
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
14
n4:projekt
n5:OVUOFVZ200805
n4:rokUplatneniVysledku
n8:2010
n4:svazekPeriodika
15
n4:tvurceVysledku
Musílek, Kamil Korábečný, Jan Fišar, Zdeněk Holas, Ondřej Marek, Jan Patocka, Jiří Zemek, Filip Kuča, Kamil Nachon, Florian Dohnal, Vlastimil Opletalová, Veronika Nepovimová, Eugenie Jun, Daniel Hroudová, Jana
n4:wos
000285709000019
n4:zamer
n19:MSM0021620822
s:issn
1420-3049
s:numberOfPages
9
n7:organizacniJednotka
G44