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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F10%3A00002297%21RIV11-MO0-G44_____
rdf:type
n6:Vysledek skos:Concept
dcterms:description
Formerly, 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine (7-MEOTA) was investigated as promising tacrine analogue beneficial for its low toxicity compared to tacrine. In this study, novel 7-MEOTA derivatives were synthesized - namely - 9,9`-di-(alkane-1,omega-diyldiimino)-di-(7-methoxy-1,2,3,4-tetrahydroacridine) was prepared from the corresponding diiodoalkanes. The novel compounds exhibit anticholinesterase (acetylcholinesterase and butyrylcholinesterase) activity in vitro. The synthesis and in vitro data are summarized in this article. Formerly, 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine (7-MEOTA) was investigated as promising tacrine analogue beneficial for its low toxicity compared to tacrine. In this study, novel 7-MEOTA derivatives were synthesized - namely - 9,9`-di-(alkane-1,omega-diyldiimino)-di-(7-methoxy-1,2,3,4-tetrahydroacridine) was prepared from the corresponding diiodoalkanes. The novel compounds exhibit anticholinesterase (acetylcholinesterase and butyrylcholinesterase) activity in vitro. The synthesis and in vitro data are summarized in this article.
dcterms:title
Synthesis and in vitro evaluation of new tacrine derivates-bis-alkylene linked 7-MEOTA Synthesis and in vitro evaluation of new tacrine derivates-bis-alkylene linked 7-MEOTA
skos:prefLabel
Synthesis and in vitro evaluation of new tacrine derivates-bis-alkylene linked 7-MEOTA Synthesis and in vitro evaluation of new tacrine derivates-bis-alkylene linked 7-MEOTA
skos:notation
RIV/60162694:G44__/10:00002297!RIV11-MO0-G44_____
n3:aktivita
n4:S n4:P n4:Z
n3:aktivity
P(OVUOFVZ200805), S, Z(MSM0021620822)
n3:cisloPeriodika
4
n3:dodaniDat
n11:2011
n3:domaciTvurceVysledku
n8:6469922 n8:6306888 n8:3876284
n3:druhVysledku
n5:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
291484
n3:idVysledku
RIV/60162694:G44__/10:00002297
n3:jazykVysledku
n9:eng
n3:klicovaSlova
acetylcholinesterase; butyrylcholinesterase; Alzheimer`s disease; tacrine; inhibition selectivity
n3:klicoveSlovo
n12:Alzheimer%60s%20disease n12:inhibition%20selectivity n12:butyrylcholinesterase n12:tacrine n12:acetylcholinesterase
n3:kodStatuVydavatele
AE - Stát Spojené arabské emiráty
n3:kontrolniKodProRIV
[165C52A24E2F]
n3:nazevZdroje
Letters in Organic Chemistry
n3:obor
n7:FR
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
7
n3:projekt
n16:OVUOFVZ200805
n3:rokUplatneniVysledku
n11:2010
n3:svazekPeriodika
7
n3:tvurceVysledku
Musílek, Kamil Kuča, Kamil Korábečný, Jan Pohanka, Miroslav Dohnal, Vlastimil Holas, Ondřej Opletalová, Veronika
n3:wos
000277156500011
n3:zamer
n13:MSM0021620822
s:issn
1570-1786
s:numberOfPages
5
n14:organizacniJednotka
G44