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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F10%3A00002243%21RIV11-GA0-G44_____
rdf:type
n13:Vysledek skos:Concept
dcterms:description
Enveloped viruses including the simian immunodeficiency virus (SIV) acquire host proteins upon egress from the host cells. Some studies have documented the potential positive and negative biological functions of such host proteins. We utilized proteomic analysis to identify differences in host proteins acquired by a single source of SIV replicating within CD4+ T cells from disease resistant sooty mangabeys (SM) and disease susceptible rhesus macaques (RM). Our results show 4 host-derived proteins that uniquely associated with SIV from RM but not SM, including 26 S protease subunit 7 (MSS1) that was shown to enhance HIV-1 'tat' mediated transactivation. Similarly, 28 host-derived proteins uniquely associated with SIV from SM, but not RM, which included several molecules associated with immune function such as CD2, TLR4, TLR9 and a bioactive form of IL-13. These proteins may have a potential role in contributing to the polarized clinical outcome in these 2 species of nonhuman primates. Enveloped viruses including the simian immunodeficiency virus (SIV) acquire host proteins upon egress from the host cells. Some studies have documented the potential positive and negative biological functions of such host proteins. We utilized proteomic analysis to identify differences in host proteins acquired by a single source of SIV replicating within CD4+ T cells from disease resistant sooty mangabeys (SM) and disease susceptible rhesus macaques (RM). Our results show 4 host-derived proteins that uniquely associated with SIV from RM but not SM, including 26 S protease subunit 7 (MSS1) that was shown to enhance HIV-1 'tat' mediated transactivation. Similarly, 28 host-derived proteins uniquely associated with SIV from SM, but not RM, which included several molecules associated with immune function such as CD2, TLR4, TLR9 and a bioactive form of IL-13. These proteins may have a potential role in contributing to the polarized clinical outcome in these 2 species of nonhuman primates.
dcterms:title
Distinct host cell proteins incorporated by SIV replicating in CD4+ T cells from natural disease resistant versus non-natural disease susceptible hosts Distinct host cell proteins incorporated by SIV replicating in CD4+ T cells from natural disease resistant versus non-natural disease susceptible hosts
skos:prefLabel
Distinct host cell proteins incorporated by SIV replicating in CD4+ T cells from natural disease resistant versus non-natural disease susceptible hosts Distinct host cell proteins incorporated by SIV replicating in CD4+ T cells from natural disease resistant versus non-natural disease susceptible hosts
skos:notation
RIV/60162694:G44__/10:00002243!RIV11-GA0-G44_____
n5:aktivita
n15:P
n5:aktivity
P(GAP304/10/1161)
n5:cisloPeriodika
1
n5:dodaniDat
n8:2011
n5:domaciTvurceVysledku
n7:3062600 n7:6008186
n5:druhVysledku
n17:J
n5:duvernostUdaju
n11:S
n5:entitaPredkladatele
n12:predkladatel
n5:idSjednocenehoVysledku
254689
n5:idVysledku
RIV/60162694:G44__/10:00002243
n5:jazykVysledku
n18:eng
n5:klicovaSlova
simian immunodeficiency virus; CD4+ T cells
n5:klicoveSlovo
n10:CD4%2B%20T%20cells n10:simian%20immunodeficiency%20virus
n5:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n5:kontrolniKodProRIV
[D43D670B6C81]
n5:nazevZdroje
Retrovirology
n5:obor
n9:EC
n5:pocetDomacichTvurcuVysledku
2
n5:pocetTvurcuVysledku
8
n5:projekt
n6:GAP304%2F10%2F1161
n5:rokUplatneniVysledku
n8:2010
n5:svazekPeriodika
7
n5:tvurceVysledku
Stephenson, ST. Boštík, Pavel Řehulka, Pavel Rajan, D. Bhimani, S. Mayne, A. E. Song, B. Ansari, A. A.
s:issn
1742-4690
s:numberOfPages
1
n16:organizacniJednotka
G44