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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F10%3A00002242%21RIV11-GA0-G44_____
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Pathogenic bacteria have developed various mechanisms to evade host immune defense systems. Invasion of pathogenic bacteria requires interaction of the pathogen with host receptors, followed by activation of signal transduction pathways and rearrangement of the cytoskeleton to facilitate bacterial entry. Numerous bacteria exploit specialized plasma membrane microdomains, commonly called membrane rafts, which are rich in cholesterol, sphingolipids and a special set of signaling molecules which allow entry to host cells and establishment of a protected niche within the host. This review focuses on the current understanding of the raft hypothesis and the means by which pathogenic bacteria subvert membrane microdomains to promote infection. Pathogenic bacteria have developed various mechanisms to evade host immune defense systems. Invasion of pathogenic bacteria requires interaction of the pathogen with host receptors, followed by activation of signal transduction pathways and rearrangement of the cytoskeleton to facilitate bacterial entry. Numerous bacteria exploit specialized plasma membrane microdomains, commonly called membrane rafts, which are rich in cholesterol, sphingolipids and a special set of signaling molecules which allow entry to host cells and establishment of a protected niche within the host. This review focuses on the current understanding of the raft hypothesis and the means by which pathogenic bacteria subvert membrane microdomains to promote infection.
dcterms:title
Membrane rafts: a potential gateway for bacterial entry into host cells Membrane rafts: a potential gateway for bacterial entry into host cells
skos:prefLabel
Membrane rafts: a potential gateway for bacterial entry into host cells Membrane rafts: a potential gateway for bacterial entry into host cells
skos:notation
RIV/60162694:G44__/10:00002242!RIV11-GA0-G44_____
n3:aktivita
n12:P n12:Z
n3:aktivity
P(GA310/07/0226), P(OVUOFVZ200808), Z(MO0FVZ0000501)
n3:cisloPeriodika
4
n3:dodaniDat
n14:2011
n3:domaciTvurceVysledku
n7:9459847 n7:5706939 n7:4407989 n7:1874896 n7:5863163
n3:druhVysledku
n10:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
270314
n3:idVysledku
RIV/60162694:G44__/10:00002242
n3:jazykVysledku
n9:eng
n3:klicovaSlova
host - pathogen interaction; intracellular bacteria; membrane rafts
n3:klicoveSlovo
n15:intracellular%20bacteria n15:membrane%20rafts n15:host
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[1D4D2CE6FBF9]
n3:nazevZdroje
Microbiology and Immunology
n3:obor
n13:EC
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n6:OVUOFVZ200808 n6:GA310%2F07%2F0226
n3:rokUplatneniVysledku
n14:2010
n3:svazekPeriodika
54
n3:tvurceVysledku
Červený, Lukáš Kročová, Zuzana Härtlová, Anetta Hubálek, Martin Stulík, Jiří
n3:wos
000276351900007
n3:zamer
n19:MO0FVZ0000501
s:issn
0385-5600
s:numberOfPages
9
n17:organizacniJednotka
G44