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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F10%3A00002233%21RIV11-GA0-G44_____
rdf:type
skos:Concept n19:Vysledek
dcterms:description
Francisella tularensis is a facultative intracellular, Gram-negative bacterium that induces apoptosis in macrophages and B cells. Here we show apoptotic pathways that are activated in the Ramos human B cell line in the course of F. tularensis infection. Live bacteria F. tularensis FSC200 activate caspases 8, 9 and 3, as well as Bid; release cytochrome c and apoptosis-inducing factor from mitochondria; and induce depolarization of mitochondrial membrane potential in the Ramos cell line, thus leading these cells to apoptosis. Unlike live bacteria, killed F. tularensis FSC200 bacteria activated only caspase 3, and did not cause apoptosis of Ramos cells as measured by annexin V. Killed bacteria also caused accumulation of anti-apoptotic protein BclxL in mitochondrial membranes. Thus, live F. tularensis activates both caspase pathways (receptor mediated and intrinsic) as well as caspase-independent mitochondrial death. Francisella tularensis is a facultative intracellular, Gram-negative bacterium that induces apoptosis in macrophages and B cells. Here we show apoptotic pathways that are activated in the Ramos human B cell line in the course of F. tularensis infection. Live bacteria F. tularensis FSC200 activate caspases 8, 9 and 3, as well as Bid; release cytochrome c and apoptosis-inducing factor from mitochondria; and induce depolarization of mitochondrial membrane potential in the Ramos cell line, thus leading these cells to apoptosis. Unlike live bacteria, killed F. tularensis FSC200 bacteria activated only caspase 3, and did not cause apoptosis of Ramos cells as measured by annexin V. Killed bacteria also caused accumulation of anti-apoptotic protein BclxL in mitochondrial membranes. Thus, live F. tularensis activates both caspase pathways (receptor mediated and intrinsic) as well as caspase-independent mitochondrial death.
dcterms:title
Activation of B cell apoptotic pathways in the course of Francisella tularensis infection Activation of B cell apoptotic pathways in the course of Francisella tularensis infection
skos:prefLabel
Activation of B cell apoptotic pathways in the course of Francisella tularensis infection Activation of B cell apoptotic pathways in the course of Francisella tularensis infection
skos:notation
RIV/60162694:G44__/10:00002233!RIV11-GA0-G44_____
n3:aktivita
n10:Z n10:I n10:P
n3:aktivity
I, P(GA310/07/0226), Z(MO0FVZ0000501), Z(MSM0021620820)
n3:cisloPeriodika
5
n3:dodaniDat
n18:2011
n3:domaciTvurceVysledku
n11:1874896 n11:9459847 n11:9905707 n11:3410722 n11:6228291 n11:5863163
n3:druhVysledku
n14:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
245278
n3:idVysledku
RIV/60162694:G44__/10:00002233
n3:jazykVysledku
n13:eng
n3:klicovaSlova
B cells; Francisella tularensis; apoptotic pathways
n3:klicoveSlovo
n4:B%20cells n4:Francisella%20tularensis n4:apoptotic%20pathways
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[E3211D6035FE]
n3:nazevZdroje
Microbial Pathogenesis
n3:obor
n17:EC
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
10
n3:projekt
n12:GA310%2F07%2F0226
n3:rokUplatneniVysledku
n18:2010
n3:svazekPeriodika
49
n3:tvurceVysledku
Kubelková, Klára Rudolf, Emil Härtlová, Anetta Hrstka, Roman Kročová, Zuzana Žáková, Jitka Stulík, Jiří Macela, Aleš Živná, Lucie
n3:wos
000281124100003
n3:zamer
n6:MO0FVZ0000501 n6:MSM0021620820
s:issn
0882-4010
s:numberOfPages
11
n5:organizacniJednotka
G44