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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F09%3A00002369%21RIV11-MO0-G44_____
rdf:type
skos:Concept n19:Vysledek
dcterms:description
The primary targets of OP, such as pesticides (paraoxon, malathion, chlorpyrifos) and nerve agents (sarin, soman, tabun, VX) are enzymes from the group of cholinesterases - AChE; EC 3.1.1.7 and; EC 3.1.1.8. Antidotes currently used for OP intoxications consist of a combination of prophylaxis with carbamates (mostly pyridostigmine) and therapy with anticholinergics (atropine), AChE oxime reactivators (pralidoxime, oxime HI-6), anticonvulsant drugs (diazepam). Another approach for prophylaxis is administration of suitable scavenger, which is capable of neutralizing OP rapidly after its penetration into organism. For these purposes, catalytic (paraoxonase, phosphotriesterase) and stoichiometric (cholinesterases) enzyme scavengers are intensively investigated. According to our results, reactivability of inhibited AChE is almost two-times higher, than that of BuChE. For construction of effective pseudocatalytic scavenger, more potent compounds are needed. The primary targets of OP, such as pesticides (paraoxon, malathion, chlorpyrifos) and nerve agents (sarin, soman, tabun, VX) are enzymes from the group of cholinesterases - AChE; EC 3.1.1.7 and; EC 3.1.1.8. Antidotes currently used for OP intoxications consist of a combination of prophylaxis with carbamates (mostly pyridostigmine) and therapy with anticholinergics (atropine), AChE oxime reactivators (pralidoxime, oxime HI-6), anticonvulsant drugs (diazepam). Another approach for prophylaxis is administration of suitable scavenger, which is capable of neutralizing OP rapidly after its penetration into organism. For these purposes, catalytic (paraoxonase, phosphotriesterase) and stoichiometric (cholinesterases) enzyme scavengers are intensively investigated. According to our results, reactivability of inhibited AChE is almost two-times higher, than that of BuChE. For construction of effective pseudocatalytic scavenger, more potent compounds are needed.
dcterms:title
Reactivation of AChE and BuChE activity - possible implications for prophylaxis against nerve agents Reactivation of AChE and BuChE activity - possible implications for prophylaxis against nerve agents
skos:prefLabel
Reactivation of AChE and BuChE activity - possible implications for prophylaxis against nerve agents Reactivation of AChE and BuChE activity - possible implications for prophylaxis against nerve agents
skos:notation
RIV/60162694:G44__/09:00002369!RIV11-MO0-G44_____
n3:aktivita
n12:P
n3:aktivity
P(OVUOFVZ200902)
n3:dodaniDat
n4:2011
n3:domaciTvurceVysledku
n8:6469922 n8:6306888 n8:7844581
n3:druhVysledku
n16:C
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
338200
n3:idVysledku
RIV/60162694:G44__/09:00002369
n3:jazykVysledku
n15:eng
n3:klicovaSlova
acetylcholinesterase; butyrylcholinesterase; pesticide; organophosphate; reactivator; oxime; bioscavenger
n3:klicoveSlovo
n9:reactivator n9:butyrylcholinesterase n9:oxime n9:acetylcholinesterase n9:bioscavenger n9:pesticide n9:organophosphate
n3:kontrolniKodProRIV
[C2C958CAF2B2]
n3:mistoVydani
Kerala
n3:nazevZdroje
Central and peripheral nervous system: effects of highly toxic organophosphates and their antidotes
n3:obor
n13:FP
n3:pocetDomacichTvurcuVysledku
3
n3:pocetStranKnihy
151
n3:pocetTvurcuVysledku
5
n3:projekt
n7:OVUOFVZ200902
n3:rokUplatneniVysledku
n4:2009
n3:tvurceVysledku
Jun, Daniel Musilová, Lucie Kuča, Kamil Musílek, Kamil Bajgar, Jiří
s:numberOfPages
9
n14:hasPublisher
Research Signpost
n18:isbn
978-81-308-0331-9
n20:organizacniJednotka
G44