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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F09%3A00002203%21RIV10-MO0-G44_____
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Acute otitis media (AOM), one of the most common childhood diseases, is associated with a substantial medical, social and economic burden. Non-typeable Haemophilus influenzae (NTHi) and Streptococcus pneumoniae are the two main causes of bacterial OM. The 7-valent pneumococcal CRM197-conjugate vaccine (7vCRM, Prevnar (TM)/Prevenar (TM), Wyeth) demonstrated efficacy against AOM caused by vaccine pneumococcal serotypes. Protection against overall AOM was also observed with an 11-valent pneumococcal protein D-conjugate vaccine (11Pn-PD) in the Pneumococcal Otitis EfficacyTrial (POET). Following POET, an optimized 10-valent pneumococcal non-typeable H. influenzae protein D-conjugate vaccine (PHiD-CV; Synflorix (TM), GlaxoSmithlKline Biologicals) was developed. This vaccine includes serotypes 1, 5, and 7F, in addition to those already included in 7vCRM, and was recently licensed in Europe for active immunization against invasive disease and AOM caused by S. pneumoniae in infants and children from 6 weeks u Acute otitis media (AOM), one of the most common childhood diseases, is associated with a substantial medical, social and economic burden. Non-typeable Haemophilus influenzae (NTHi) and Streptococcus pneumoniae are the two main causes of bacterial OM. The 7-valent pneumococcal CRM197-conjugate vaccine (7vCRM, Prevnar (TM)/Prevenar (TM), Wyeth) demonstrated efficacy against AOM caused by vaccine pneumococcal serotypes. Protection against overall AOM was also observed with an 11-valent pneumococcal protein D-conjugate vaccine (11Pn-PD) in the Pneumococcal Otitis EfficacyTrial (POET). Following POET, an optimized 10-valent pneumococcal non-typeable H. influenzae protein D-conjugate vaccine (PHiD-CV; Synflorix (TM), GlaxoSmithlKline Biologicals) was developed. This vaccine includes serotypes 1, 5, and 7F, in addition to those already included in 7vCRM, and was recently licensed in Europe for active immunization against invasive disease and AOM caused by S. pneumoniae in infants and children from 6 weeks u
dcterms:title
Prevention of otitis media: Now a reality? Prevention of otitis media: Now a reality?
skos:prefLabel
Prevention of otitis media: Now a reality? Prevention of otitis media: Now a reality?
skos:notation
RIV/60162694:G44__/09:00002203!RIV10-MO0-G44_____
n3:aktivita
n6:Z
n3:aktivity
Z(MO0FVZ0000502)
n3:cisloPeriodika
42
n3:dodaniDat
n15:2010
n3:domaciTvurceVysledku
n18:3938913
n3:druhVysledku
n11:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
335864
n3:idVysledku
RIV/60162694:G44__/09:00002203
n3:jazykVysledku
n17:eng
n3:klicovaSlova
otitis; Streptococcus pneumoniae
n3:klicoveSlovo
n12:Streptococcus%20pneumoniae n12:otitis
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[89FA5CCBF6F3]
n3:nazevZdroje
Vaccine
n3:obor
n13:FN
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n15:2009
n3:svazekPeriodika
27
n3:tvurceVysledku
Hoet, B. Forsgren, A. Prymula, Roman Borys, D. Schuerman, L.
n3:zamer
n10:MO0FVZ0000502
s:issn
0264-410X
s:numberOfPages
7
n14:organizacniJednotka
G44