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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F09%3A00002132%21RIV10-MO0-G44_____
rdf:type
skos:Concept n15:Vysledek
dcterms:description
Huperzine A (Hup A) is a reversible AChE inhibitor that crosses the blood-brain barrier. It is presently approved for human use or is in course of clinical trials for the treatment of Alzheimer's disease. This compound has also been successfully tested for pretreatment of organophosphate poisoning. Organophosphate nerve agents are potent irreversible inhibitors of acetylcholinesterase in central and also in peripheral compartment. In this study Hup A in higher dose (500 µg/kg) was tested as a prophylaxis against high mainly centrally acting nerve agents (soman). According to the obtained results, Hup A in this dose was not able to protect AChE in both peripheral and central compartment against soman. Additive affect of Hup A and soman was found and all animals died. Huperzine A (Hup A) is a reversible AChE inhibitor that crosses the blood-brain barrier. It is presently approved for human use or is in course of clinical trials for the treatment of Alzheimer's disease. This compound has also been successfully tested for pretreatment of organophosphate poisoning. Organophosphate nerve agents are potent irreversible inhibitors of acetylcholinesterase in central and also in peripheral compartment. In this study Hup A in higher dose (500 µg/kg) was tested as a prophylaxis against high mainly centrally acting nerve agents (soman). According to the obtained results, Hup A in this dose was not able to protect AChE in both peripheral and central compartment against soman. Additive affect of Hup A and soman was found and all animals died.
dcterms:title
Is high dose of Huperzine A really suitable for pretreatment of higher dose of soman? Is high dose of Huperzine A really suitable for pretreatment of higher dose of soman?
skos:prefLabel
Is high dose of Huperzine A really suitable for pretreatment of higher dose of soman? Is high dose of Huperzine A really suitable for pretreatment of higher dose of soman?
skos:notation
RIV/60162694:G44__/09:00002132!RIV10-MO0-G44_____
n3:aktivita
n13:Z
n3:aktivity
Z(MO0FVZ0000501)
n3:cisloPeriodika
2
n3:dodaniDat
n6:2010
n3:domaciTvurceVysledku
n5:6306888 n5:4898737 n5:7844581 n5:1182021
n3:druhVysledku
n11:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
320447
n3:idVysledku
RIV/60162694:G44__/09:00002132
n3:jazykVysledku
n9:eng
n3:klicovaSlova
Huperzine A; soman; brain; nerve agent; acetylcholinesterase; pretreatment
n3:klicoveSlovo
n7:soman n7:acetylcholinesterase n7:brain n7:pretreatment n7:Huperzine%20A n7:nerve%20agent
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[D1DCAC2F9940]
n3:nazevZdroje
Journal of Applied Biomedicine
n3:obor
n12:FP
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n6:2009
n3:svazekPeriodika
7
n3:tvurceVysledku
Bajgar, Jiří Kuča, Kamil Novotný, Ladislav Žďárová Karasová, Jana
n3:wos
000267953800003
n3:zamer
n18:MO0FVZ0000501
s:issn
1214-0287
s:numberOfPages
7
n14:organizacniJednotka
G44