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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F09%3A00002130%21RIV10-MO0-G44_____
rdf:type
n15:Vysledek skos:Concept
dcterms:description
The toxic effect of organophosphates is attributed to irreversible inhibition acetylcholinesterase (AChE; EC 3.1.1.7), the enzyme that hydrolyses the neurotransmitter acetylcholine. Inhibition potency in vivo of one of the most toxic nerve agent - Russian VX (RVX; N,N-diethyl-2-[methyl-(2-methylpropoxy)phosphoryl]sulfanylethanamine) (1 x LD50 dose administered intramuscularly, i.m.) was studied in rats. AChE in blood was inhibited by 50%, 3 min after i.m. RVX. Butyrylcholinesterase (BChE; EC 3.1.1.8) in plasma was inhibited less rapidly and only 10-20%, 20 min after RVX. AChE and BChE activities in diaphragm were reduced only 30% and 15% at 30 min. While AChE and BChE activities were reduced only 20% and 15%, respectively, the decline in activity was rapid, occurring within 3 min. These findings indicate that RVX most potent inhibits ChE outsider the central nervous system. The toxic effect of organophosphates is attributed to irreversible inhibition acetylcholinesterase (AChE; EC 3.1.1.7), the enzyme that hydrolyses the neurotransmitter acetylcholine. Inhibition potency in vivo of one of the most toxic nerve agent - Russian VX (RVX; N,N-diethyl-2-[methyl-(2-methylpropoxy)phosphoryl]sulfanylethanamine) (1 x LD50 dose administered intramuscularly, i.m.) was studied in rats. AChE in blood was inhibited by 50%, 3 min after i.m. RVX. Butyrylcholinesterase (BChE; EC 3.1.1.8) in plasma was inhibited less rapidly and only 10-20%, 20 min after RVX. AChE and BChE activities in diaphragm were reduced only 30% and 15% at 30 min. While AChE and BChE activities were reduced only 20% and 15%, respectively, the decline in activity was rapid, occurring within 3 min. These findings indicate that RVX most potent inhibits ChE outsider the central nervous system.
dcterms:title
Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX
skos:prefLabel
Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX
skos:notation
RIV/60162694:G44__/09:00002130!RIV10-MO0-G44_____
n3:aktivita
n13:Z n13:S
n3:aktivity
S, Z(MO0FVZ0000604)
n3:cisloPeriodika
4
n3:dodaniDat
n7:2010
n3:domaciTvurceVysledku
n6:7844581 n6:4185137 n6:4898737 n6:6306888
n3:druhVysledku
n17:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
346365
n3:idVysledku
RIV/60162694:G44__/09:00002130
n3:jazykVysledku
n5:eng
n3:klicovaSlova
Russian VX; acetylcholinesterase; butyrylcholinesterase; nerve agent
n3:klicoveSlovo
n4:acetylcholinesterase n4:nerve%20agent n4:butyrylcholinesterase n4:Russian%20VX
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[49A3257B715E]
n3:nazevZdroje
Neurotoxicity Research
n3:obor
n18:FP
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n7:2009
n3:svazekPeriodika
16
n3:tvurceVysledku
Bajgar, Jiří Kuča, Kamil Žďárová Karasová, Jana Jun, Daniel Pavlikova, Růžena
n3:wos
000271028000002
n3:zamer
n8:MO0FVZ0000604
s:issn
1029-8428
s:numberOfPages
5
n12:organizacniJednotka
G44