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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F09%3A00002128%21RIV11-MO0-G44_____
rdf:type
skos:Concept n12:Vysledek
dcterms:description
Seven new oxime-based acetylcholinesterase reactivators were compared with three currently available oximes (obidoxime, trimedoxime, HI-6) for their ability to lessen cholinesterase inhibition in blood and brain of cyclosarin-treated rats. Oximes were given at doses of 5% their LD50 along with 21 mg/kg atropine 5 min before the LD50 of cyclosarin (120 ug/kg). Blood and brain samples were collected 30 minutes later. The greatest difference between acetylcholinesterase inhibition in blood of cyclosarin-treated rats was found after administration of HI-6 (40%), compared to 22% for trimedoxime and 6% for obidoxime. Only 2 of the 7 newly synthesized oximes had any effect (K203 at 7%, K156 at 5%). Effective oximes against cyclosarin-inhibited plasma butyrylcholinesterase were HI-6 (42%), trimedoxime (11%), and K156 (4%). The oximes were less effective in brain than in blood, with reactivation values for HI-6 30% against acetylcholinesterase and 10% against butyrylcholinesterase. Values for newly synt Seven new oxime-based acetylcholinesterase reactivators were compared with three currently available oximes (obidoxime, trimedoxime, HI-6) for their ability to lessen cholinesterase inhibition in blood and brain of cyclosarin-treated rats. Oximes were given at doses of 5% their LD50 along with 21 mg/kg atropine 5 min before the LD50 of cyclosarin (120 ug/kg). Blood and brain samples were collected 30 minutes later. The greatest difference between acetylcholinesterase inhibition in blood of cyclosarin-treated rats was found after administration of HI-6 (40%), compared to 22% for trimedoxime and 6% for obidoxime. Only 2 of the 7 newly synthesized oximes had any effect (K203 at 7%, K156 at 5%). Effective oximes against cyclosarin-inhibited plasma butyrylcholinesterase were HI-6 (42%), trimedoxime (11%), and K156 (4%). The oximes were less effective in brain than in blood, with reactivation values for HI-6 30% against acetylcholinesterase and 10% against butyrylcholinesterase. Values for newly synt
dcterms:title
Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats
skos:prefLabel
Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats
skos:notation
RIV/60162694:G44__/09:00002128!RIV11-MO0-G44_____
n5:aktivita
n15:Z
n5:aktivity
Z(MO0FVZ0000501)
n5:cisloPeriodika
7
n5:dodaniDat
n10:2011
n5:domaciTvurceVysledku
n6:3876284 n6:1182021 n6:2182262 n6:6306888 n6:6469922 n6:4898737
n5:druhVysledku
n8:J
n5:duvernostUdaju
n14:S
n5:entitaPredkladatele
n17:predkladatel
n5:idSjednocenehoVysledku
312253
n5:idVysledku
RIV/60162694:G44__/09:00002128
n5:jazykVysledku
n18:eng
n5:klicovaSlova
acetylcholinesterase; butyrylcholinesterase; reactivators; oximes; cyclosarin
n5:klicoveSlovo
n13:oximes n13:butyrylcholinesterase n13:acetylcholinesterase n13:reactivators n13:cyclosarin
n5:kodStatuVydavatele
CH - Švýcarská konfederace
n5:kontrolniKodProRIV
[8A5EE32CEFF1]
n5:nazevZdroje
International Journal of Molecular Sciences
n5:obor
n9:FP
n5:pocetDomacichTvurcuVysledku
6
n5:pocetTvurcuVysledku
6
n5:rokUplatneniVysledku
n10:2009
n5:svazekPeriodika
10
n5:tvurceVysledku
Žďárová Karasová, Jana Pohanka, Miroslav Musílek, Kamil Kuča, Kamil Kassa, Jiří Novotný, Ladislav
n5:wos
000268317300013
n5:zamer
n16:MO0FVZ0000501
s:issn
1422-0067
s:numberOfPages
11
n11:organizacniJednotka
G44