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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F08%3A00001994%21RIV09-MO0-G44_____
rdf:type
skos:Concept n11:Vysledek
dcterms:description
Běžná léčba otrav organofosfáty spočívá v podání anticholinergik a reaktivátorů (oximů). Oximy mohou reagovat, mimo vlastních cholinesteráz, přímo s cholinergními receptory. HI-6 je oxim který může toto působení vykazovat také. V této práci byl zkoumán vliv reaktivátoru HI-6 an acetylcholinesterázu (AChE) a butyrylcholinesterázu (BChE) a in vitro na muskarinové receptory. Studie byla realizována za použití biosenzoru, respektive testování tkání. Byly stanoveny hodnoty IC50 pro BChE a AChE. Ve studii byl vysloven předpoklad inhibice AChE při nižších koncentracích reaktivátoru a inhibici muskarinových receptorů při vyšších koncentracích. OBJECTIVES: The current standard treatment of organophosphate poisoning consists of an administration of anticholinergic drugs and cholinesterase reactivators (oximes). Oximes can react - except their reactivating effect on cholinesterases - directly with cholinoreceptors. HI-6 is an oxime that may have an inhibitory effect on the muscarinic receptors, too. METHODS: In our work, we have investigated an influence of HI-6 on the acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and on the muscarinic receptors in vitro. The study was conducted using biosensor technique and on the rat bladder using in vitro test (tissue bath; methacholine as muscarinic agonist). IC50 for BChE from human serum was determined to be 1.01x10-6 M and for human erythrocytes AChE 3.31x10-6 M, respectively. CONCLUSION: We assume that the demonstrated contractile response can be attributed to the inhibition of the AChE at the lower concentration and to a predominant inhibition of muscarinic receptor at higher concentration OBJECTIVES: The current standard treatment of organophosphate poisoning consists of an administration of anticholinergic drugs and cholinesterase reactivators (oximes). Oximes can react - except their reactivating effect on cholinesterases - directly with cholinoreceptors. HI-6 is an oxime that may have an inhibitory effect on the muscarinic receptors, too. METHODS: In our work, we have investigated an influence of HI-6 on the acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and on the muscarinic receptors in vitro. The study was conducted using biosensor technique and on the rat bladder using in vitro test (tissue bath; methacholine as muscarinic agonist). IC50 for BChE from human serum was determined to be 1.01x10-6 M and for human erythrocytes AChE 3.31x10-6 M, respectively. CONCLUSION: We assume that the demonstrated contractile response can be attributed to the inhibition of the AChE at the lower concentration and to a predominant inhibition of muscarinic receptor at higher concentration
dcterms:title
The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder Působení látky HI-6 na cholinesterázy a krysí močový měchýř The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder
skos:prefLabel
The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder Působení látky HI-6 na cholinesterázy a krysí močový měchýř
skos:notation
RIV/60162694:G44__/08:00001994!RIV09-MO0-G44_____
n3:aktivita
n5:Z
n3:aktivity
Z(MO0FVZ0000604)
n3:cisloPeriodika
5
n3:dodaniDat
n13:2009
n3:domaciTvurceVysledku
n8:4185137 n8:2182262 n8:4488695 n8:6306888 n8:6469922 n8:3876284
n3:druhVysledku
n12:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
365114
n3:idVysledku
RIV/60162694:G44__/08:00001994
n3:jazykVysledku
n14:eng
n3:klicovaSlova
HI-6; reactivator; cholinesterase; acetylcholinesterase; inhibition
n3:klicoveSlovo
n4:cholinesterase n4:HI-6 n4:reactivator n4:acetylcholinesterase n4:inhibition
n3:kodStatuVydavatele
SE - Švédské království
n3:kontrolniKodProRIV
[F9BBB51B1049]
n3:nazevZdroje
Neuroendocrinology Letters
n3:obor
n15:FP
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
8
n3:rokUplatneniVysledku
n13:2008
n3:svazekPeriodika
29
n3:tvurceVysledku
Kuča, Kamil Kassa, Jiří Fusek, Josef Marek, Jan Musílek, Kamil Jun, Daniel Pohanka, Miroslav Soukup, Ondřej
n3:wos
000261553200031
n3:zamer
n17:MO0FVZ0000604
s:issn
0172-780X
s:numberOfPages
4
n10:organizacniJednotka
G44