This HTML5 document contains 51 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n3http://localhost/temp/predkladatel/
n16http://linked.opendata.cz/resource/domain/vavai/projekt/
n12http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n11http://linked.opendata.cz/ontology/domain/vavai/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n4http://linked.opendata.cz/ontology/domain/vavai/riv/
n18http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F60162694%3AG44__%2F08%3A00001983%21RIV09-MO0-G44_____/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n9http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n8http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n17http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n14http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n7http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n5http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n13http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F08%3A00001983%21RIV09-MO0-G44_____
rdf:type
skos:Concept n11:Vysledek
dcterms:description
Organophosphorus pesticides (e.g. chlorpyrifos, malathion, and parathion) and nerve agents (sarin, tabun, and VX) are highly toxic organophosphorus compounds with strong inhibition potency against two key enzymes in the human body-acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8). Subsequent accumulation of acetylcholine at synaptic clefts can result in cholinergic crisis and possible death of intoxicated organism. For the recovery of inhibited AChE, derivatives from the group of pyridinium or bispyridinium aldoximes (called oximes) are used. Their efficacy depends on their chemical structure and also type of organophosphorus inhibitor. In this study, we have tested potency of selected cholinesterase reactivators (pralidoxime, obidoxime, trimedoxime, methoxime and H-oxime HI-6) to reactivate human erythrocyte AChE and human plasma BuChE inhibited by pesticide paraoxon. For this purpose, modified Ellman's method was used and two different concentrations of oxime Organophosphorus pesticides (e.g. chlorpyrifos, malathion, and parathion) and nerve agents (sarin, tabun, and VX) are highly toxic organophosphorus compounds with strong inhibition potency against two key enzymes in the human body-acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8). Subsequent accumulation of acetylcholine at synaptic clefts can result in cholinergic crisis and possible death of intoxicated organism. For the recovery of inhibited AChE, derivatives from the group of pyridinium or bispyridinium aldoximes (called oximes) are used. Their efficacy depends on their chemical structure and also type of organophosphorus inhibitor. In this study, we have tested potency of selected cholinesterase reactivators (pralidoxime, obidoxime, trimedoxime, methoxime and H-oxime HI-6) to reactivate human erythrocyte AChE and human plasma BuChE inhibited by pesticide paraoxon. For this purpose, modified Ellman's method was used and two different concentrations of oxime Organofosforové pesticidy (např. chlorpyrifos, malathion a parathion) a nervově paralytické látky (sarin, tabun a VX) jsou vysoce toxické organofosfáty s vysokou inhibiční schopností vůči dvěma klíčovým enzymům v lidském těle - acetylcholinesteráze (AChE; EC 3.1.1.7) a butyrylcholinesteráze (BuChE; EC 3.1.1.8). Následné nahromadění acetylcholinu v synaptických štěrbinách může vyústit v cholinergní krizi a smrt intoxikovaného organizmu. Pro obnovu aktivity inhibované AChE jsou užívány deriváty ze skupiny pyridinových a bispyridiniových reaktivátorů (nazývané oximy). Jejich účinnost závisí na jejich chemické struktuře a struktuře organofosforového inhibitoru. V této studii jsme otestovali schopnost vybraných reaktivátorů cholinesteráz (pralidoxim, obidoxim, trimedoxim, methoxim a H-oxim HI-6) reaktivovat lidskou erytrocytární AChE a plazmatickou BuChE inhibovanou pesticidem paraoxon. Pro testování byla použita modifikovaná metoda podle Ellmana, látky byly měřeny ve dvou koncentracích (10 a 100 μM)
dcterms:title
Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro Schopnost vybraných oximů reaktivovat lidskou acetylcholinesterázu a butyrylcholinesterázu inhibovanou paraoxonem in vitro Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro
skos:prefLabel
Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro Schopnost vybraných oximů reaktivovat lidskou acetylcholinesterázu a butyrylcholinesterázu inhibovanou paraoxonem in vitro Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro
skos:notation
RIV/60162694:G44__/08:00001983!RIV09-MO0-G44_____
n4:aktivita
n17:P
n4:aktivity
P(OPUOFVZ200603)
n4:cisloPeriodika
1
n4:dodaniDat
n13:2009
n4:domaciTvurceVysledku
n12:6306888 n12:4185137 n12:4657853
n4:druhVysledku
n5:J
n4:duvernostUdaju
n8:S
n4:entitaPredkladatele
n18:predkladatel
n4:idSjednocenehoVysledku
388082
n4:idVysledku
RIV/60162694:G44__/08:00001983
n4:jazykVysledku
n14:eng
n4:klicovaSlova
acetylcholinesterase; butyrylcholinesterase; pesticide; organophosphate; reactivator; oxime; bioscavenger
n4:klicoveSlovo
n9:organophosphate n9:bioscavenger n9:oxime n9:reactivator n9:pesticide n9:butyrylcholinesterase n9:acetylcholinesterase
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[9DECD2F52EB5]
n4:nazevZdroje
Drug and Chemical Toxicology
n4:obor
n7:FP
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
5
n4:projekt
n16:OPUOFVZ200603
n4:rokUplatneniVysledku
n13:2008
n4:svazekPeriodika
31
n4:tvurceVysledku
Pícha, Jan Marek, Jan Kuča, Kamil Kolečkář, Vít Jun, Daniel
n4:wos
000252323200001
s:issn
0148-0545
s:numberOfPages
9
n3:organizacniJednotka
G44