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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F08%3A00001982%21RIV09-MO0-G44_____
rdf:type
skos:Concept n9:Vysledek
dcterms:description
Organophosphorus pesticides (e.g. chlorpyrifos, malathion, and parathion) and nerve agents (sarin, tabun, and VX) are highly toxic organophosphorus compounds with strong inhibition potency against two key enzymes in the human body-acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8). Subsequent accumulation of acetylcholine at synaptic clefts can result in cholinergic crisis and possible death of intoxicated organism. For the recovery of inhibited AChE, derivatives from the group of pyridinium or bispyridinium aldoximes (called oximes) are used. Their efficacy depends on their chemical structure and also type of organophosphorus inhibitor. In this study, we have tested potency of selected cholinesterase reactivators (pralidoxime, obidoxime, trimedoxime, methoxime and H-oxime HI-6) to reactivate human erythrocyte AChE and human plasma BuChE inhibited by pesticide paraoxon. For this purpose, modified Ellman's method was used and two different concentrations of oxime Organophosphorus pesticides (e.g. chlorpyrifos, malathion, and parathion) and nerve agents (sarin, tabun, and VX) are highly toxic organophosphorus compounds with strong inhibition potency against two key enzymes in the human body-acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8). Subsequent accumulation of acetylcholine at synaptic clefts can result in cholinergic crisis and possible death of intoxicated organism. For the recovery of inhibited AChE, derivatives from the group of pyridinium or bispyridinium aldoximes (called oximes) are used. Their efficacy depends on their chemical structure and also type of organophosphorus inhibitor. In this study, we have tested potency of selected cholinesterase reactivators (pralidoxime, obidoxime, trimedoxime, methoxime and H-oxime HI-6) to reactivate human erythrocyte AChE and human plasma BuChE inhibited by pesticide paraoxon. For this purpose, modified Ellman's method was used and two different concentrations of oxime Organofosforové pesticidy (např. chlorpyrifos, malathion a parathion) a nervově paralytické látky (sarin, tabun a VX) jsou vysoce toxické organofosfáty s vysokou inhibiční schopností vůči dvěma klíčovým enzymům v lidském těle - acetylcholinesteráze (AChE; EC 3.1.1.7) a butyrylcholinesteráze (BuChE; EC 3.1.1.8). Následné nahromadění acetylcholinu v synaptických štěrbinách může vyústit v cholinergní krizi a smrt intoxikovaného organizmu. Pro obnovu aktivity inhibované AChE jsou užívány deriváty ze skupiny pyridinových a bispyridiniových reaktivátorů (nazývané oximy). Jejich účinnost závisí na jejich chemické struktuře a struktuře organofosforového inhibitoru. V této studii jsme otestovali schopnost vybraných reaktivátorů cholinesteráz (pralidoxim, obidoxim, trimedoxim, methoxim a H-oxim HI-6) reaktivovat lidskou erytrocytární AChE a plazmatickou BuChE inhibovanou pesticidem paraoxon. Pro testování byla použita modifikovaná metoda podle Ellmana, látky byly měřeny ve dvou koncentracích (10 a 100 μM)
dcterms:title
Schopnost vybraných oximů reaktivovat lidskou acetylcholinesterázu a butyrylcholinesterázu inhibovanou paraoxonem in vitro Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro
skos:prefLabel
Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro Schopnost vybraných oximů reaktivovat lidskou acetylcholinesterázu a butyrylcholinesterázu inhibovanou paraoxonem in vitro Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro
skos:notation
RIV/60162694:G44__/08:00001982!RIV09-MO0-G44_____
n4:aktivita
n15:S n15:P
n4:aktivity
P(OPUOFVZ200603), S
n4:cisloPeriodika
1-3
n4:dodaniDat
n11:2009
n4:domaciTvurceVysledku
n13:4185137 n13:7844581 n13:2182262
n4:druhVysledku
n17:J
n4:duvernostUdaju
n10:S
n4:entitaPredkladatele
n12:predkladatel
n4:idSjednocenehoVysledku
388081
n4:idVysledku
RIV/60162694:G44__/08:00001982
n4:jazykVysledku
n16:eng
n4:klicovaSlova
acetylcholinesterase; butyrylcholinesterase; pesticide; organophosphate; reactivator; oxime; bioscavenger
n4:klicoveSlovo
n5:butyrylcholinesterase n5:bioscavenger n5:pesticide n5:acetylcholinesterase n5:organophosphate n5:oxime n5:reactivator
n4:kodStatuVydavatele
IE - Irsko
n4:kontrolniKodProRIV
[613E982005DB]
n4:nazevZdroje
Chemico-Biological Interactions
n4:obor
n18:FP
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
5
n4:projekt
n14:OPUOFVZ200603
n4:rokUplatneniVysledku
n11:2008
n4:svazekPeriodika
175
n4:tvurceVysledku
Bajgar, Jiří Kassa, Jiří Kuča, Kamil Musilová, Lucie Jun, Daniel
n4:wos
000260110500081
s:issn
0009-2797
s:numberOfPages
4
n7:organizacniJednotka
G44