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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F07%3A00001823%21RIV10-MO0-G44_____
rdf:type
skos:Concept n18:Vysledek
dcterms:description
As it is generally known, different anions of pharmaceutical preparations are generally developed to achieve better pharmacological effect through their adsorption phase. In this article, reactivation potency of twelve salts (sulfate, chloride, acetate, bromide, phosphate, mesylate, tartarate, iodide, malonate, salicylate, maleinate, tosylate) of bisquaternary acetylcholinesterase reactivator HI-6 was tested to elucidate that chemically different anions have no effect on the reactivation of nerve agent-inhibited acetylcholinesterase. For this purpose, cyclosarin was taken as the appropriate member of the nerve agent family. It was found that the use of different salts has no effect on the reactivation potency. As it is generally known, different anions of pharmaceutical preparations are generally developed to achieve better pharmacological effect through their adsorption phase. In this article, reactivation potency of twelve salts (sulfate, chloride, acetate, bromide, phosphate, mesylate, tartarate, iodide, malonate, salicylate, maleinate, tosylate) of bisquaternary acetylcholinesterase reactivator HI-6 was tested to elucidate that chemically different anions have no effect on the reactivation of nerve agent-inhibited acetylcholinesterase. For this purpose, cyclosarin was taken as the appropriate member of the nerve agent family. It was found that the use of different salts has no effect on the reactivation potency.
dcterms:title
Twelve different HI-6 salts and their potency to reactivate cyclosarin inhibited AChE in vitro Twelve different HI-6 salts and their potency to reactivate cyclosarin inhibited AChE in vitro
skos:prefLabel
Twelve different HI-6 salts and their potency to reactivate cyclosarin inhibited AChE in vitro Twelve different HI-6 salts and their potency to reactivate cyclosarin inhibited AChE in vitro
skos:notation
RIV/60162694:G44__/07:00001823!RIV10-MO0-G44_____
n4:aktivita
n16:P n16:V n16:Z
n4:aktivity
P(FI-IM2/104), V, Z(MO0FVZ0000501)
n4:cisloPeriodika
7
n4:dodaniDat
n9:2010
n4:domaciTvurceVysledku
n7:4185137 n7:6306888 n7:6469922 n7:4641531 n7:2182262
n4:druhVysledku
n13:J
n4:duvernostUdaju
n19:S
n4:entitaPredkladatele
n15:predkladatel
n4:idSjednocenehoVysledku
456103
n4:idVysledku
RIV/60162694:G44__/07:00001823
n4:jazykVysledku
n10:eng
n4:klicovaSlova
HI-6; reactivator; acetylcholinesterase; cyclosarine; nerve agent; salt; ion exchange; antidote; oxime; quaternary nitrogen
n4:klicoveSlovo
n5:ion%20exchange n5:oxime n5:cyclosarine n5:HI-6 n5:reactivator n5:antidote n5:acetylcholinesterase n5:quaternary%20nitrogen n5:nerve%20agent n5:salt
n4:kodStatuVydavatele
AE - Stát Spojené arabské emiráty
n4:kontrolniKodProRIV
[CE8C9B402567]
n4:nazevZdroje
Letters in Drug Design and Discovery
n4:obor
n17:FP
n4:pocetDomacichTvurcuVysledku
5
n4:pocetTvurcuVysledku
9
n4:projekt
n12:FI-IM2%2F104
n4:rokUplatneniVysledku
n9:2007
n4:svazekPeriodika
4
n4:tvurceVysledku
Kassa, Jiří Stodůlka, Petr Hrabinová, Martina Marek, J. Hanusová, P. Musílek, Kamil Kuča, Kamil Jun, Daniel Doležal, B.
n4:wos
000250176100010
n4:zamer
n14:MO0FVZ0000501
s:issn
1570-1808
s:numberOfPages
3
n6:organizacniJednotka
G44