This HTML5 document contains 48 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n7http://localhost/temp/predkladatel/
n9http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n10http://linked.opendata.cz/ontology/domain/vavai/
n17http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F60162694%3AG44__%2F07%3A00001815%21RIV08-MO0-G44_____/
n13http://linked.opendata.cz/resource/domain/vavai/zamer/
shttp://schema.org/
n4http://linked.opendata.cz/ontology/domain/vavai/riv/
skoshttp://www.w3.org/2004/02/skos/core#
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n5http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n14http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n18http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n11http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n16http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n15http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n6http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F07%3A00001815%21RIV08-MO0-G44_____
rdf:type
skos:Concept n10:Vysledek
dcterms:description
Pomocí alignmentřu byly porovnány AChE jednotlivých živočišných druhů. Acetylcholinesterase (AChE) is a widely spread enzyme playing a very important role in nerve signal transmission. As AChE controls key processes, its inhibition leads to the very fast death of an organism, including humans. However, when this feature is to be used for killing of unwanted organisms (i.e. mosquitoes), one is faced with the question - how much do AChEs differ between species and what are the differences? Here, a theoretical point of view was utilized to identify the structural basis for such differences. The various primary and tertiary alignments show that AChEs are very evolutionary conserved enzymes and this fact could lead to difficulties, for example, in the search for inhibitors specific for a particular species. Acetylcholinesterase (AChE) is a widely spread enzyme playing a very important role in nerve signal transmission. As AChE controls key processes, its inhibition leads to the very fast death of an organism, including humans. However, when this feature is to be used for killing of unwanted organisms (i.e. mosquitoes), one is faced with the question - how much do AChEs differ between species and what are the differences? Here, a theoretical point of view was utilized to identify the structural basis for such differences. The various primary and tertiary alignments show that AChEs are very evolutionary conserved enzymes and this fact could lead to difficulties, for example, in the search for inhibitors specific for a particular species.
dcterms:title
AChE - strukturní shodnosti a rozličnosti Acetylcholinesterases - the structural similarities and differences Acetylcholinesterases - the structural similarities and differences
skos:prefLabel
AChE - strukturní shodnosti a rozličnosti Acetylcholinesterases - the structural similarities and differences Acetylcholinesterases - the structural similarities and differences
skos:notation
RIV/60162694:G44__/07:00001815!RIV08-MO0-G44_____
n4:strany
417-424
n4:aktivita
n11:Z
n4:aktivity
Z(MO0FVZ0000604)
n4:cisloPeriodika
4
n4:dodaniDat
n6:2008
n4:domaciTvurceVysledku
n9:6306888 n9:4185137
n4:druhVysledku
n15:J
n4:duvernostUdaju
n14:S
n4:entitaPredkladatele
n17:predkladatel
n4:idSjednocenehoVysledku
408413
n4:idVysledku
RIV/60162694:G44__/07:00001815
n4:jazykVysledku
n18:eng
n4:klicovaSlova
acetylcholinesterase; active site; peripheral anionic site; alignment; protein fold
n4:klicoveSlovo
n5:acetylcholinesterase n5:alignment n5:peripheral%20anionic%20site n5:active%20site n5:protein%20fold
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[7BFE51009EF5]
n4:nazevZdroje
Journal of Enzyme Inhibition and Medicinal Chemistry
n4:obor
n16:FP
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
5
n4:rokUplatneniVysledku
n6:2007
n4:svazekPeriodika
22
n4:tvurceVysledku
Kriz, Z. Jun, Daniel Kuča, Kamil Koca, J. Wiesner, J.
n4:zamer
n13:MO0FVZ0000604
s:issn
1475-6366
s:numberOfPages
8
n7:organizacniJednotka
G44