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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F07%3A00001810%21RIV10-MO0-G44_____
rdf:type
n3:Vysledek skos:Concept
dcterms:description
The chemical structures of certain drug candidates give only a minimum of lipophilicity. Investigation of their elution on reversed-phase materials was difficult, even when the water content of the mobile phase was changed. The dominative role of lipophilicity, either in the drugs' penetration or in the receptorial drug binding, is considered to be valid solely in the same chemical group of the various drugs. In the cases of extremely lipophobic (i.e., hydrophilic) compounds, both the determination or calculation of lipophilicity was difficult or impossible. This is the reason that a novel index, the TLC hydrophilicity parameter, should be introduced as a substitute for lipophilicity. Hydrophilicity can be preferrably determined using a planar stationary phase and an aqueous-organic mobile phase. Numerical data of hydrophilicity on silica stationary phase can be calculated using RM values, similar to the lipophilicity indices. The chemical structures of certain drug candidates give only a minimum of lipophilicity. Investigation of their elution on reversed-phase materials was difficult, even when the water content of the mobile phase was changed. The dominative role of lipophilicity, either in the drugs' penetration or in the receptorial drug binding, is considered to be valid solely in the same chemical group of the various drugs. In the cases of extremely lipophobic (i.e., hydrophilic) compounds, both the determination or calculation of lipophilicity was difficult or impossible. This is the reason that a novel index, the TLC hydrophilicity parameter, should be introduced as a substitute for lipophilicity. Hydrophilicity can be preferrably determined using a planar stationary phase and an aqueous-organic mobile phase. Numerical data of hydrophilicity on silica stationary phase can be calculated using RM values, similar to the lipophilicity indices.
dcterms:title
The TLC determination of hydrophilicity parameter of some pyridinium aldoximes The TLC determination of hydrophilicity parameter of some pyridinium aldoximes
skos:prefLabel
The TLC determination of hydrophilicity parameter of some pyridinium aldoximes The TLC determination of hydrophilicity parameter of some pyridinium aldoximes
skos:notation
RIV/60162694:G44__/07:00001810!RIV10-MO0-G44_____
n4:aktivita
n13:N
n4:aktivity
N
n4:cisloPeriodika
15
n4:dodaniDat
n16:2010
n4:domaciTvurceVysledku
n11:6306888
n4:druhVysledku
n12:J
n4:duvernostUdaju
n6:S
n4:entitaPredkladatele
n10:predkladatel
n4:idSjednocenehoVysledku
455266
n4:idVysledku
RIV/60162694:G44__/07:00001810
n4:jazykVysledku
n15:eng
n4:klicovaSlova
Pyridinium aldoximes; Hydrophylicity; TLC; Silica; RM values
n4:klicoveSlovo
n8:Silica n8:TLC n8:Hydrophylicity n8:RM%20values n8:Pyridinium%20aldoximes
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[6216AA9E3A78]
n4:nazevZdroje
Journal of Liquid Chromatography & Related Technologies
n4:obor
n17:FP
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
7
n4:rokUplatneniVysledku
n16:2007
n4:svazekPeriodika
30
n4:tvurceVysledku
Csermely, T. Bathori, M. Kuča, Kamil Laufer, R. Kalasz, H. Toth, N. Petroianu, G.
n4:wos
000248539300038
s:issn
1082-6076
s:numberOfPages
8
n14:organizacniJednotka
G44