This HTML5 document contains 47 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n8http://localhost/temp/predkladatel/
n14http://linked.opendata.cz/resource/domain/vavai/projekt/
n13http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n15http://linked.opendata.cz/ontology/domain/vavai/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n18http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F60162694%3AG44__%2F07%3A00001809%21RIV09-GA0-G44_____/
n4http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n16http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n9http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n6http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n12http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n10http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n7http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F07%3A00001809%21RIV09-GA0-G44_____
rdf:type
skos:Concept n15:Vysledek
dcterms:description
Strukturní faktory ovlivňující schopnost v současnosti užívaných reaktivátorů AChE léčit cyklosarinové intoxikace. Cyclosarin is one member of nerve agents´ family. Recent treatment of intoxications by organophosphorus compounds, such as nerve agents or pesticides, consists of rapid administration of anticholinergics and AChE reactivators. Owing to the threat of terroristic use of these compounds during last years, improvement of antidotal therapy still continues. As the part of the development of new antidotes, many new AChE reactivators were synthesized and currently some of them are under consideration for introducing them to the medical praxis. Their biological activity depends, as in the case of other drugs, on their chemical structure, which affects their pharmacokinetic (adsorption, distribution, metabolism and excretion) and pharmacodynamics. In this review, we would like to discuss relationship between structure of currently available AChE reactivators and their potency to reactivate cyclosarin-inhibited AChE. All outlined structural factors presented in this work should be helpful for the design of new Cyclosarin is one member of nerve agents´ family. Recent treatment of intoxications by organophosphorus compounds, such as nerve agents or pesticides, consists of rapid administration of anticholinergics and AChE reactivators. Owing to the threat of terroristic use of these compounds during last years, improvement of antidotal therapy still continues. As the part of the development of new antidotes, many new AChE reactivators were synthesized and currently some of them are under consideration for introducing them to the medical praxis. Their biological activity depends, as in the case of other drugs, on their chemical structure, which affects their pharmacokinetic (adsorption, distribution, metabolism and excretion) and pharmacodynamics. In this review, we would like to discuss relationship between structure of currently available AChE reactivators and their potency to reactivate cyclosarin-inhibited AChE. All outlined structural factors presented in this work should be helpful for the design of new
dcterms:title
Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications Strukturní faktory ovlivňující schopnost v současnosti užívaných reaktivátorů AChE léčit cyklosarinové intoxikace
skos:prefLabel
Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications Strukturní faktory ovlivňující schopnost v současnosti užívaných reaktivátorů AChE léčit cyklosarinové intoxikace Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications
skos:notation
RIV/60162694:G44__/07:00001809!RIV09-GA0-G44_____
n3:aktivita
n6:P
n3:aktivity
P(GP305/07/P162)
n3:cisloPeriodika
33
n3:dodaniDat
n7:2009
n3:domaciTvurceVysledku
n13:6306888 n13:4185137 n13:7844581
n3:druhVysledku
n10:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
452860
n3:idVysledku
RIV/60162694:G44__/07:00001809
n3:jazykVysledku
n9:eng
n3:klicovaSlova
Acetylcholinesterase; nerve agent; antidotes; cyclosarin; reactivators; oxime
n3:klicoveSlovo
n4:cyclosarin n4:antidotes n4:reactivators n4:nerve%20agent n4:Acetylcholinesterase n4:oxime
n3:kodStatuVydavatele
AE - Stát Spojené arabské emiráty
n3:kontrolniKodProRIV
[944234A38792]
n3:nazevZdroje
Current Pharmaceutical Design
n3:obor
n12:FP
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:projekt
n14:GP305%2F07%2FP162
n3:rokUplatneniVysledku
n7:2007
n3:svazekPeriodika
13
n3:tvurceVysledku
Kuča, Kamil Bajgar, Jiří Jun, Daniel
s:issn
1381-6128
s:numberOfPages
8
n8:organizacniJednotka
G44