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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F07%3A00001761%21RIV08-MO0-G44_____
rdf:type
n15:Vysledek skos:Concept
dcterms:description
Oba nově vyvinuté oximy (K074, K075) stejně jako obidoxim jsou schopny redukovat cyklosarinem indukovanou akutní neurotoxicitu, ale jejich neuroprotektivní účinnost je signifikantně nižší ve srovnání s oximem HI-6. Proto je oxim HI-6 stále nejvhodnějším oximem pro antidotní terapii akutní otravy cyklosarinem vzhledem k jeho neuroprotektivní a reaktivační účinnosti. Both newly developed oximes (K074, K075) as well as obidoxime are also able to counteract cyclosarin-induced acute neurotoxicity but their neuroprotective potency is significantly lower compared to the oxime HI-6. Therefore, the oxime HI-6 is still the most suitable oxime for the antidotal treatment of acute poisonings with cyclosarin due to its neuroprotective as well as reactivating efficacy. Both newly developed oximes (K074, K075) as well as obidoxime are also able to counteract cyclosarin-induced acute neurotoxicity but their neuroprotective potency is significantly lower compared to the oxime HI-6. Therefore, the oxime HI-6 is still the most suitable oxime for the antidotal treatment of acute poisonings with cyclosarin due to its neuroprotective as well as reactivating efficacy.
dcterms:title
The evaluation of neuroprotective efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats Vyhodnocení neuroprotektivního účinku nově vyvinutých oximů (K074, K075) a v současnosti dostupných oximů (obidoxim, HI-6) na potkanech otrávených cyklosarinem The evaluation of neuroprotective efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats
skos:prefLabel
The evaluation of neuroprotective efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats The evaluation of neuroprotective efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats Vyhodnocení neuroprotektivního účinku nově vyvinutých oximů (K074, K075) a v současnosti dostupných oximů (obidoxim, HI-6) na potkanech otrávených cyklosarinem
skos:notation
RIV/60162694:G44__/07:00001761!RIV08-MO0-G44_____
n3:strany
621-630
n3:aktivita
n5:Z
n3:aktivity
Z(MO0FVZ0000501)
n3:cisloPeriodika
6
n3:dodaniDat
n11:2008
n3:domaciTvurceVysledku
n14:2182262 n14:4898737
n3:druhVysledku
n18:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
420761
n3:idVysledku
RIV/60162694:G44__/07:00001761
n3:jazykVysledku
n12:eng
n3:klicovaSlova
cyclosarin; atropine; K oximes; HI-6; obidoxime; functional observational battery
n3:klicoveSlovo
n8:K%20oximes n8:functional%20observational%20battery n8:HI-6 n8:atropine n8:obidoxime n8:cyclosarin
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[1118888C9347]
n3:nazevZdroje
Journal of Applied Toxicology
n3:obor
n13:FP
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
3
n3:rokUplatneniVysledku
n11:2007
n3:svazekPeriodika
27
n3:tvurceVysledku
Karasová, Jana Vašina, Libor Kassa, Jiří
n3:zamer
n6:MO0FVZ0000501
s:issn
0260-437X
s:numberOfPages
10
n16:organizacniJednotka
G44