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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F07%3A00001753%21RIV08-MO0-G44_____
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Due to their reactivating effects, both newly developed K oximes can be considered to be promising oximes for the antidotal treatment of acute tabun poisonings while the oxime HI-6 is still the most promising oxime for the treatment of acute cyclosarin poisonings due to its high potency to reactivate cyclosarin-inhibited acetylcholinesterase in the peripheral as well as central compartment. Due to their reactivating effects, both newly developed K oximes can be considered to be promising oximes for the antidotal treatment of acute tabun poisonings while the oxime HI-6 is still the most promising oxime for the treatment of acute cyclosarin poisonings due to its high potency to reactivate cyclosarin-inhibited acetylcholinesterase in the peripheral as well as central compartment. Díky reaktivačnímu účinku mohou být K oximy považovány za slibné oximy pro antidotní terapii akutní otravy tabunem, zatímco oxim HI-6 je stále nejslibnějším oximem pro terapii akutní atravy cyklosarinem díky vysoké schopnosti reaktivovat cyklosarinem inhibovanou acetylcholinesterázu v periferním i centrálním kompártmentu.
dcterms:title
A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin- and tabun-poisoned rats Srovnání reaktivační účinnosti nově vyvinutých oximů (K074, K075) a v současnosti dostupných oximů (obidoxim, HI-6) na cyklosarinem a tabunem otrávených potkanech A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin- and tabun-poisoned rats
skos:prefLabel
A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin- and tabun-poisoned rats Srovnání reaktivační účinnosti nově vyvinutých oximů (K074, K075) a v současnosti dostupných oximů (obidoxim, HI-6) na cyklosarinem a tabunem otrávených potkanech A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin- and tabun-poisoned rats
skos:notation
RIV/60162694:G44__/07:00001753!RIV08-MO0-G44_____
n3:strany
297-300
n3:aktivita
n9:Z
n3:aktivity
Z(MO0FVZ0000501)
n3:cisloPeriodika
3
n3:dodaniDat
n12:2008
n3:domaciTvurceVysledku
n14:4185137 n14:2182262 n14:6306888
n3:druhVysledku
n13:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
407832
n3:idVysledku
RIV/60162694:G44__/07:00001753
n3:jazykVysledku
n15:eng
n3:klicovaSlova
tabun; cyclosarin; acetylcholinesterase; reactivation; oximes; rat; inhibition
n3:klicoveSlovo
n8:inhibition n8:acetylcholinesterase n8:oximes n8:tabun n8:cyclosarin n8:reactivation n8:rat
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[6D51B111B503]
n3:nazevZdroje
Journal of Enzyme Inhibition and Medicinal Chemistry
n3:obor
n11:FP
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:rokUplatneniVysledku
n12:2007
n3:svazekPeriodika
22
n3:tvurceVysledku
Kassa, Jiří Jun, Daniel Kuča, Kamil
n3:zamer
n10:MO0FVZ0000501
s:issn
1475-6366
s:numberOfPages
4
n18:organizacniJednotka
G44