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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F06%3A00001491%21RIV07-MO0-G44_____
rdf:type
skos:Concept n14:Vysledek
dcterms:description
Nerve agents (sarin, tabun, soman and VX) are class of military important substances able to cause many severe intoxications during few minutes. Currently, the threat of misuse of these agents is daily discussed.Unfortunately, there is no single antidote able to treat intoxication caused by all of these agents. Owing to this fact, new generation of antidotes, especially acetylcholinesterase (AChE; EC 3.1.1.7) reactivators, is still developed. In this study, we have tested four newly developed AChE reactivators: 1-(4-hydroxyiminomethylpyridinium)-5-(4-carbamoylpyridinium)-3-oxa-pentane dibromide (1), 1-(3-hydroxyiminomethylpyridinium)-5-(4-carbamoylpyridinium)-3-oxa-pentane dibromide (2), 1,5-bis(2-hydroxyiminomethylpyridinium)-3-oxa-pentane dichloride (3) and 1,5-bis(4-hydroxyiminomethylpyridinium)-3-oxa-pentane dibromide (4) for their potency to reactivate in vitro tabun and cyclosarin-inhibited AChE. Their reactivation efficacy was compared with currently the most promising oxime HI-6 (1-(2-hydroxy Nerve agents (sarin, tabun, soman and VX) are class of military important substances able to cause many severe intoxications during few minutes. Currently, the threat of misuse of these agents is daily discussed.Unfortunately, there is no single antidote able to treat intoxication caused by all of these agents. Owing to this fact, new generation of antidotes, especially acetylcholinesterase (AChE; EC 3.1.1.7) reactivators, is still developed. In this study, we have tested four newly developed AChE reactivators: 1-(4-hydroxyiminomethylpyridinium)-5-(4-carbamoylpyridinium)-3-oxa-pentane dibromide (1), 1-(3-hydroxyiminomethylpyridinium)-5-(4-carbamoylpyridinium)-3-oxa-pentane dibromide (2), 1,5-bis(2-hydroxyiminomethylpyridinium)-3-oxa-pentane dichloride (3) and 1,5-bis(4-hydroxyiminomethylpyridinium)-3-oxa-pentane dibromide (4) for their potency to reactivate in vitro tabun and cyclosarin-inhibited AChE. Their reactivation efficacy was compared with currently the most promising oxime HI-6 (1-(2-hydroxy V této práci byly testovány nové reaktivátory AChE (Korea, Daejon # KRICT) pro jejich schopnost reaktivovat AChE inhibovanou nervově paralytickými látkami # tabun a cyklosarin
dcterms:title
In vitro evaluation of new acetylcholinesterase reactivators as casual antidotes against tabun and cyclosarin In vitro zhodnocení nových reaktivátorů acetylcholinesterázy jako kauzálních antidot proti tabunu a cyklosarinu In vitro evaluation of new acetylcholinesterase reactivators as casual antidotes against tabun and cyclosarin
skos:prefLabel
In vitro zhodnocení nových reaktivátorů acetylcholinesterázy jako kauzálních antidot proti tabunu a cyklosarinu In vitro evaluation of new acetylcholinesterase reactivators as casual antidotes against tabun and cyclosarin In vitro evaluation of new acetylcholinesterase reactivators as casual antidotes against tabun and cyclosarin
skos:notation
RIV/60162694:G44__/06:00001491!RIV07-MO0-G44_____
n3:strany
395-398
n3:aktivita
n15:P
n3:aktivity
P(OBVLAJEP20032), P(ONVLAJEP20031)
n3:cisloPeriodika
3
n3:dodaniDat
n17:2007
n3:domaciTvurceVysledku
n10:6306888 n10:4185137 n10:3691314
n3:druhVysledku
n11:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
479135
n3:idVysledku
RIV/60162694:G44__/06:00001491
n3:jazykVysledku
n16:eng
n3:klicovaSlova
Acetylcholinesterase reactivators; Antidote; Organophosphorus intoxication; Cyclosarin; Tabun; Oxime
n3:klicoveSlovo
n4:Organophosphorus%20intoxication n4:Oxime n4:Tabun n4:Cyclosarin n4:Acetylcholinesterase%20reactivators n4:Antidote
n3:kodStatuVydavatele
KR - Korejská republika
n3:kontrolniKodProRIV
[007707ADA9E3]
n3:nazevZdroje
Bulletin of the Korean Chemical Society
n3:obor
n5:FP
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
5
n3:projekt
n13:ONVLAJEP20031 n13:OBVLAJEP20032
n3:rokUplatneniVysledku
n17:2006
n3:svazekPeriodika
27
n3:tvurceVysledku
Jung, Y. S. Kim, T. H. Cabal, Jiří Kuča, Kamil Jun, Daniel
s:issn
0253-2964
s:numberOfPages
4
n18:organizacniJednotka
G44