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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F06%3A00001490%21RIV07-MO0-G44_____
rdf:type
n8:Vysledek skos:Concept
dcterms:description
Antidotes currently used in the case of organophosphorus pesticide and nerve agent intoxications consist of anticholinergics (atropine mainly) and acetylcholinesterase (AChE, EC 3.1.1.7) reactivators called oximes. Owing to the wide-spread of these compounds worldwide, development of antidotes for the case of the first aid is needed. To select the most promising AChE reactivators is very time consuming process, which is necessary before approval of these compounds to be used as human antidotes. Because of ethical reasons, many developing experiments have been conducted on laboratory animals. However, these results could not be often transferred directly to human. Due to this fact, in our work, we have tested five newly developed AChE reactivators # K027, K033, K048, K074 and K075, which achieved promising reactivation activity on rodents, as reactivators of human brain cholinesterases. For this purpose, cyclosarin was used as member of the nerve agent family. H-oxime HI-6 and pralidoxime were used as Antidotes currently used in the case of organophosphorus pesticide and nerve agent intoxications consist of anticholinergics (atropine mainly) and acetylcholinesterase (AChE, EC 3.1.1.7) reactivators called oximes. Owing to the wide-spread of these compounds worldwide, development of antidotes for the case of the first aid is needed. To select the most promising AChE reactivators is very time consuming process, which is necessary before approval of these compounds to be used as human antidotes. Because of ethical reasons, many developing experiments have been conducted on laboratory animals. However, these results could not be often transferred directly to human. Due to this fact, in our work, we have tested five newly developed AChE reactivators # K027, K033, K048, K074 and K075, which achieved promising reactivation activity on rodents, as reactivators of human brain cholinesterases. For this purpose, cyclosarin was used as member of the nerve agent family. H-oxime HI-6 and pralidoxime were used as Schopnost nově vyvinuých reaktivátorů acetylcholinesterázy (K027, K033, K048, K074 a K075) byla testována na cholinesterázách lidského mozku inhibovaných nervově paralytickou látkou cyklosarin.
dcterms:title
Potency of new structurally different oximes to reactivate cyclosarin inhibited-human brain acetylcholinesterases Schopnost nových strukturně odlišných oximů reaktivovat cyclosarinem inhibovanou acetylcholinesterázu z lidského mozku Potency of new structurally different oximes to reactivate cyclosarin inhibited-human brain acetylcholinesterases
skos:prefLabel
Schopnost nových strukturně odlišných oximů reaktivovat cyclosarinem inhibovanou acetylcholinesterázu z lidského mozku Potency of new structurally different oximes to reactivate cyclosarin inhibited-human brain acetylcholinesterases Potency of new structurally different oximes to reactivate cyclosarin inhibited-human brain acetylcholinesterases
skos:notation
RIV/60162694:G44__/06:00001490!RIV07-MO0-G44_____
n4:strany
663-666
n4:aktivita
n13:Z
n4:aktivity
Z(MO0FVZ0000501)
n4:cisloPeriodika
6
n4:dodaniDat
n7:2007
n4:domaciTvurceVysledku
n9:3691314 n9:4641531 n9:4185137 n9:7844581 n9:6306888
n4:druhVysledku
n15:J
n4:duvernostUdaju
n10:S
n4:entitaPredkladatele
n12:predkladatel
n4:idSjednocenehoVysledku
493375
n4:idVysledku
RIV/60162694:G44__/06:00001490
n4:jazykVysledku
n14:eng
n4:klicovaSlova
cholinesterase; reactivator; cyclosarin; human brain; nerve agent
n4:klicoveSlovo
n11:cholinesterase n11:reactivator n11:cyclosarin n11:human%20brain n11:nerve%20agent
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[6A0CC4783224]
n4:nazevZdroje
Journal of Enzyme Inhibition and Medicinal Chemistry
n4:obor
n16:FP
n4:pocetDomacichTvurcuVysledku
5
n4:pocetTvurcuVysledku
5
n4:rokUplatneniVysledku
n7:2006
n4:tvurceVysledku
Jun, Daniel Hrabinová, Martina Kuča, Kamil Bajgar, Jiří Cabal, Jiří
n4:zamer
n17:MO0FVZ0000501
s:issn
1475-6366
s:numberOfPages
4
n18:organizacniJednotka
G44