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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F06%3A00001456%21RIV07-MO0-G44_____
rdf:type
skos:Concept n18:Vysledek
dcterms:description
Oximes are cholinesterase reactivators used in organophosphorus poisoning. Clinical experience with pralidoxime (PRX) and other oximes is disappointing and their routine use has been questioned. In addition it is known that not all oximes are equally effective against all existing organophosphorus compounds. There is a demand for broad-spectrum reactivators with a higher efficacy than PRX. Based on our previous in vitro work the protection conferred by the various new oximes against inhibition by paraoxon as quantified by the IC(50) shift (nM increase in the IC(50) of the inhibitor per microM oxime present) is: 0.3 (PRX), 0.4 (methoxime; MMC-4), 1 (K-33), 1.2 (BI-6), 1.5 (K-48) and 3.7 (K-27). The purpose of the study was to quantify in vivo the extent of oxime-conferred protection, using paraoxon (POX) as a cholinesterase inhibitor and to test whether in vitro efficacy translates to protection from mortality. There were seven groups of six rats in each cycle of the experiment. Group 1 (G1) received 1 Byly testovány nové reaktivátory AChE # K033, K027 a K048 pro svou schopnost reaktivovat erythrocytální AChE inhibovanou pesticidem paraoxonem pomocí metody in vivo (potkan). Oximes are cholinesterase reactivators used in organophosphorus poisoning. Clinical experience with pralidoxime (PRX) and other oximes is disappointing and their routine use has been questioned. In addition it is known that not all oximes are equally effective against all existing organophosphorus compounds. There is a demand for broad-spectrum reactivators with a higher efficacy than PRX. Based on our previous in vitro work the protection conferred by the various new oximes against inhibition by paraoxon as quantified by the IC(50) shift (nM increase in the IC(50) of the inhibitor per microM oxime present) is: 0.3 (PRX), 0.4 (methoxime; MMC-4), 1 (K-33), 1.2 (BI-6), 1.5 (K-48) and 3.7 (K-27). The purpose of the study was to quantify in vivo the extent of oxime-conferred protection, using paraoxon (POX) as a cholinesterase inhibitor and to test whether in vitro efficacy translates to protection from mortality. There were seven groups of six rats in each cycle of the experiment. Group 1 (G1) received 1
dcterms:title
Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: survival in rats exposed to the organophosphate paraoxon Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: survival in rats exposed to the organophosphate paraoxon Pět oximů (K-27, K-33, K-48, BI-6 a methoxim) ve srovnání s pralidoximem: přežití potkanů exponovaných organofosfátem paraoxonem
skos:prefLabel
Pět oximů (K-27, K-33, K-48, BI-6 a methoxim) ve srovnání s pralidoximem: přežití potkanů exponovaných organofosfátem paraoxonem Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: survival in rats exposed to the organophosphate paraoxon Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: survival in rats exposed to the organophosphate paraoxon
skos:notation
RIV/60162694:G44__/06:00001456!RIV07-MO0-G44_____
n3:strany
262-268
n3:aktivita
n16:P
n3:aktivity
P(OBVLAJEP20032)
n3:cisloPeriodika
3
n3:dodaniDat
n9:2007
n3:domaciTvurceVysledku
n10:6306888 n10:2182262
n3:druhVysledku
n14:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
475969
n3:idVysledku
RIV/60162694:G44__/06:00001456
n3:jazykVysledku
n17:eng
n3:klicovaSlova
oximes; paraoxon; acetylcholinesterase; reactivator
n3:klicoveSlovo
n4:reactivator n4:oximes n4:paraoxon n4:acetylcholinesterase
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[55AE07EAE8B5]
n3:nazevZdroje
Journal of Applied Toxicology
n3:obor
n15:FP
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
6
n3:projekt
n11:OBVLAJEP20032
n3:rokUplatneniVysledku
n9:2006
n3:svazekPeriodika
26
n3:tvurceVysledku
Kassa, Jiří Al-sultan, M. A. H. Petroianu, G. A. Nurulain, S. M. Kuča, Kamil Negelkerke, N.
s:issn
0260-437X
s:numberOfPages
7
n5:organizacniJednotka
G44