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Statements

Subject Item
n2:RIV%2F60162694%3AG42__%2F07%3A%230000338%21RIV07-MO0-G42_____
rdf:type
skos:Concept n18:Vysledek
dcterms:description
Byla studována účinnost reaktivátorů 2-PAM, TMB-4, HI-6 a Toxogoninu při reaktivaci acetylcholinesterázy inhibované látkou R-33. Ke studiu byla využita acetylcholinesteráza imobilizovaná a stabilizovaná na bavlněné textilii a indikační papír s acetylthiocholin jodidem a kyselinou 5,5´-dithiobis(2-nitrobenzoovou). Aktivita enzymu byla zjišťována měřením remisních změn povrchu textilie, které jsou způsobené reakcí produktů enzymové hydrolýzy substrátu s chromogenním činidlem. Nejúčinnějším ze studovaných reaktivátorů byl 2-PAM v koncentracích 0,5 mg.cm-3 a 0,1 mg.cm-3. HI-6 byl v těchto koncentracích méně účinný. Vyšší účinnost byla zaznamená až po 20 min v koncentraci 0,05 mg.cm-3 a 0,01 mg.cm-3, kde převyšovala 2-PAM. U TMB-4 a Toxogoninu byly po 10 min zaznamenané hodnoty reaktivace kolem 10 %, po 20 min byly tyto reaktivátory neúčinné. - Efficacy of reactivators 2-PAM, TMB-4, HI-6 and toxogonin in reactivation of acetylcholinesterase inhibited by compound R 33 has been studied. The study was performed with acetylcholinesterase immobilized and stabilized on a cotton fabric and with an indicator paper with acetylthiocholine iodide and 5,5´ dithiobis(2 nitrobenzoic acid). The enzyme activity was determined by measurement of remission changes of the fabric surface, caused by reaction of the chromogenic reagent with products of enzymatic hydrolysis of the substrate. The most potent of the reactivators studied was 2-PAM at concentrations 0.5 mg.cm-3 and 0.1 mg.cm-3. Effectivity of this reactivator was over 20 %. At these concentrations, reactivator HI-6 was less effective. Efficacy higher than that of 2-PAM was observed only after 20 min at concentrations 0.05 mg.cm-3 and 0.01 mg.cm-3. For TMB-4 and toxogonin the reactivation values were about 10 % after 10 min whereas after 15 or 20 min these reactivators were ineffective. - Efficacy of reactivators 2-PAM, TMB-4, HI-6 and toxogonin in reactivation of acetylcholinesterase inhibited by compound R 33 has been studied. The study was performed with acetylcholinesterase immobilized and stabilized on a cotton fabric and with an indicator paper with acetylthiocholine iodide and 5,5´ dithiobis(2 nitrobenzoic acid). The enzyme activity was determined by measurement of remission changes of the fabric surface, caused by reaction of the chromogenic reagent with products of enzymatic hydrolysis of the substrate. The most potent of the reactivators studied was 2-PAM at concentrations 0.5 mg.cm-3 and 0.1 mg.cm-3. Effectivity of this reactivator was over 20 %. At these concentrations, reactivator HI-6 was less effective. Efficacy higher than that of 2-PAM was observed only after 20 min at concentrations 0.05 mg.cm-3 and 0.01 mg.cm-3. For TMB-4 and toxogonin the reactivation values were about 10 % after 10 min whereas after 15 or 20 min these reactivators were ineffective.
dcterms:title
Efficacy of 2-PAM, TMB-4, HI-6 and toxogonin in reactivation of immobilized acetylcholinesterase inhibited by compound R-33 Efficacy of 2-PAM, TMB-4, HI-6 and toxogonin in reactivation of immobilized acetylcholinesterase inhibited by compound R-33 Účinnost 2-PAM, TMB-4, HI-6 a Toxogoninu při reaktivaci imobilizované acetylcholinesterázy inhibované látkou R-33
skos:prefLabel
Efficacy of 2-PAM, TMB-4, HI-6 and toxogonin in reactivation of immobilized acetylcholinesterase inhibited by compound R-33 Účinnost 2-PAM, TMB-4, HI-6 a Toxogoninu při reaktivaci imobilizované acetylcholinesterázy inhibované látkou R-33 Efficacy of 2-PAM, TMB-4, HI-6 and toxogonin in reactivation of immobilized acetylcholinesterase inhibited by compound R-33
skos:notation
RIV/60162694:G42__/07:#0000338!RIV07-MO0-G42_____
n3:strany
161-164
n3:aktivita
n15:Z
n3:aktivity
Z(MO0UOPZHN0401)
n3:cisloPeriodika
3
n3:dodaniDat
n4:2007
n3:domaciTvurceVysledku
n13:1241737 n13:7978995 n13:2887630
n3:druhVysledku
n6:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
419333
n3:idVysledku
RIV/60162694:G42__/07:#0000338
n3:jazykVysledku
n11:eng
n3:klicovaSlova
Acetylcholinesterasa, inhibition, Vx, R-33, reactivation, 2-PAM, TMB-4, HI-6, Toxogonin
n3:klicoveSlovo
n9:HI-6 n9:Toxogonin n9:Acetylcholinesterasa n9:R-33 n9:inhibition n9:2-PAM n9:Vx n9:TMB-4 n9:reactivation
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[4A8D2971214C]
n3:nazevZdroje
Toxicology Mechanisms and Methods
n3:obor
n8:KA
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n4:2007
n3:svazekPeriodika
17
n3:tvurceVysledku
Kobliha, Zbyněk Halámek, Emil Tušarová, Ivana Hoskovcová, Monika
n3:zamer
n17:MO0UOPZHN0401
s:issn
1537-6524
s:numberOfPages
4
n10:organizacniJednotka
G42