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Statements

Subject Item
n2:RIV%2F60162694%3AG38__%2F09%3A%230000142%21RIV10-MO0-G38_____
rdf:type
skos:Concept n8:Vysledek
dcterms:description
Quantification of efficiency of monopyridinium isomers and homologs derived from clinical used pralidoxim within reactivation of acetylcholinesterase inhibited with organophosphorus nerve agents. This work uses the colorimetric biosensor called Detehit – cotton cloth with immobilized enzyme acetylcholinesterase. Biosensor is based on the modificated Ellman method. The highest reactivation was observed with sarin-inhibited acetylcholinesterase. Substantially lower reactivation was found with the cyclosarin-inhibited enzyme whereas AChE, inhibited by soman could not be effectively reactivated under the given conditions enzyme inhibition for 2 minutes and subsequent treatment with the reactivator for 15 minutes. Our work gives comparison of efficiency of reactivators in dependence on the lenght of alkylene chain and position of aldoxime functional group. Evaluation of effectivity of aldoxime reactivators is provided by simple means. Quantification of efficiency of monopyridinium isomers and homologs derived from clinical used pralidoxim within reactivation of acetylcholinesterase inhibited with organophosphorus nerve agents. This work uses the colorimetric biosensor called Detehit – cotton cloth with immobilized enzyme acetylcholinesterase. Biosensor is based on the modificated Ellman method. The highest reactivation was observed with sarin-inhibited acetylcholinesterase. Substantially lower reactivation was found with the cyclosarin-inhibited enzyme whereas AChE, inhibited by soman could not be effectively reactivated under the given conditions enzyme inhibition for 2 minutes and subsequent treatment with the reactivator for 15 minutes. Our work gives comparison of efficiency of reactivators in dependence on the lenght of alkylene chain and position of aldoxime functional group. Evaluation of effectivity of aldoxime reactivators is provided by simple means.
dcterms:title
Efficacy of structural homoloques and isomers of pralidoxime in reactivation of immobilised acetylcholinesterase inhibited with sarin, cyclosarin and soman Efficacy of structural homoloques and isomers of pralidoxime in reactivation of immobilised acetylcholinesterase inhibited with sarin, cyclosarin and soman
skos:prefLabel
Efficacy of structural homoloques and isomers of pralidoxime in reactivation of immobilised acetylcholinesterase inhibited with sarin, cyclosarin and soman Efficacy of structural homoloques and isomers of pralidoxime in reactivation of immobilised acetylcholinesterase inhibited with sarin, cyclosarin and soman
skos:notation
RIV/60162694:G38__/09:#0000142!RIV10-MO0-G38_____
n4:aktivita
n6:Z
n4:aktivity
Z(MO0UOPZHN0401)
n4:cisloPeriodika
1
n4:dodaniDat
n11:2010
n4:domaciTvurceVysledku
n12:2887630 n12:7978995 n12:1241737
n4:druhVysledku
n17:J
n4:duvernostUdaju
n10:S
n4:entitaPredkladatele
n15:predkladatel
n4:idSjednocenehoVysledku
312479
n4:idVysledku
RIV/60162694:G38__/09:#0000142
n4:jazykVysledku
n16:eng
n4:klicovaSlova
acetylcholinesterase; acetylcholinesterase reactivators; chemical warfare agents; nerve agent; pralidoxime; sarin; cyclosarin; soman
n4:klicoveSlovo
n9:chemical%20warfare%20agents n9:acetylcholinesterase n9:sarin n9:cyclosarin n9:soman n9:pralidoxime n9:acetylcholinesterase%20reactivators n9:nerve%20agent
n4:kodStatuVydavatele
SE - Švédské království
n4:kontrolniKodProRIV
[F318FC0A5EA9]
n4:nazevZdroje
Neuroendocrinology Letters
n4:obor
n18:KA
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
3
n4:rokUplatneniVysledku
n11:2009
n4:svazekPeriodika
30
n4:tvurceVysledku
Halámek, Emil Kobliha, ZBYNĚK Hoskovcová, Monika
n4:wos
000261553200013
n4:zamer
n5:MO0UOPZHN0401
s:issn
0172-780X
s:numberOfPages
4
n14:organizacniJednotka
G38