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Statements

Subject Item
n2:RIV%2F60162694%3AG38__%2F04%3A00001082%21RIV%2F2005%2FMO0%2FG38005%2FN
rdf:type
n7:Vysledek skos:Concept
dcterms:description
We have tested four new bisquaternary pyridinium acetylcholinesterase (AChE; EC 3.1.1.7) reactivators - K005 (1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide), K033 (1,4-bis(2-hydroxyiminomethylpyridinium) butane dibromide), K027 (1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium) propane dibromide) and K048 (1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane dibromide) as the potential reactivators of AChE inhibited by cyclosarin. Their reactivation potencies were studied using standard in vitro reactivation test. Rat brain homogenate was used as the source of the enzyme. Oxime K033 seems to be the most potent reactivator of cyclosarin-inhibited AChE. Its reactivation potency is significantly higher than the efficacy of all other tested AChE reactivators. In vitro reaktivace acetylcholinesterazy inhibované cyklosarinem užitím biskvartérních aldoximů K005, K033, K027 a K048 We have tested four new bisquaternary pyridinium acetylcholinesterase (AChE; EC 3.1.1.7) reactivators - K005 (1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide), K033 (1,4-bis(2-hydroxyiminomethylpyridinium) butane dibromide), K027 (1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium) propane dibromide) and K048 (1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane dibromide) as the potential reactivators of AChE inhibited by cyclosarin. Their reactivation potencies were studied using standard in vitro reactivation test. Rat brain homogenate was used as the source of the enzyme. Oxime K033 seems to be the most potent reactivator of cyclosarin-inhibited AChE. Its reactivation potency is significantly higher than the efficacy of all other tested AChE reactivators.
dcterms:title
In vitro reactivation of acetylcholinesterase inhibited by cyclosarin using bisquaternary pyridinium aldoximes K005, K033, K027 and K048 In vitro reactivation of acetylcholinesterase inhibited by cyclosarin using bisquaternary pyridinium aldoximes K005, K033, K027 and K048 In vitro reaktivace acetylcholinesterazy inhibované cyklosarinem užitím biskvartérních aldoximů K005, K033, K027 a K048
skos:prefLabel
In vitro reactivation of acetylcholinesterase inhibited by cyclosarin using bisquaternary pyridinium aldoximes K005, K033, K027 and K048 In vitro reactivation of acetylcholinesterase inhibited by cyclosarin using bisquaternary pyridinium aldoximes K005, K033, K027 and K048 In vitro reaktivace acetylcholinesterazy inhibované cyklosarinem užitím biskvartérních aldoximů K005, K033, K027 a K048
skos:notation
RIV/60162694:G38__/04:00001082!RIV/2005/MO0/G38005/N
n3:strany
107-109
n3:aktivita
n18:P
n3:aktivity
P(ONVLAJEP20031)
n3:cisloPeriodika
2
n3:dodaniDat
n14:2005
n3:domaciTvurceVysledku
n17:6306888
n3:druhVysledku
n5:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
567629
n3:idVysledku
RIV/60162694:G38__/04:00001082
n3:jazykVysledku
n13:eng
n3:klicovaSlova
Cyclosarin;in vitro;reactivation;inhibition;acetylcholinesterase;K005;K033;K027;K048;oximes;nerve agents;GF agent;cyclosin
n3:klicoveSlovo
n4:K005 n4:GF%20agent n4:oximes n4:K048 n4:K027 n4:nerve%20agents n4:acetylcholinesterase n4:inhibition n4:cyclosin n4:reactivation n4:in%20vitro n4:Cyclosarin n4:K033
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[0E7D1BF951AE]
n3:nazevZdroje
Acta Medica (Hradec Králové)
n3:obor
n9:FP
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
3
n3:projekt
n16:ONVLAJEP20031
n3:rokUplatneniVysledku
n14:2004
n3:svazekPeriodika
47
n3:tvurceVysledku
Kuča, Kamil Ševelová-Bartošová, Lucie Krejčová-Kunešová, Gabriela
s:issn
1211-4286
s:numberOfPages
3
n15:organizacniJednotka
G38