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Statements

Subject Item
n2:RIV%2F60162694%3AG38__%2F04%3A00001080%21RIV%2F2005%2FMO0%2FG38005%2FN
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Cyclohexyl methylphosphonofluoridate (cyclosarin, cyclosin, GF) is a highly toxic organophosphate, which was resistant to conventional oxime therapy. To give more insight into the reactivation kinetics, rat brain acetylcholinesterase (AChE) was inhibited in vitro by cyclosarin (pH 8.0, 25 °C) and reactivated with 22 different pyridinium-oximes. Only three compounds were shown to be superior to the other oximes: 4-carbamoyl-4´-[(hydroxyimino)methyl]-1,1´-(oxydimethylene)dipyridin-1-ium dichloride (HS-6), 4´-carbamoyl-2-[(hydroxyimino)methyl]-1,1´-(oxydimethylene)dipyridin-1-ium dichloride (HI-6), and 4´-carbamoyl-2-[(hydroxyimino)methyl]-1,1´-(but-2-ene-1,4-diyl)dipyridin-1-ium dichloride (BI-6). Reaktivace cyklosarinem inhibované acetylcholinesterázy pyridiniovými oximy Cyclohexyl methylphosphonofluoridate (cyclosarin, cyclosin, GF) is a highly toxic organophosphate, which was resistant to conventional oxime therapy. To give more insight into the reactivation kinetics, rat brain acetylcholinesterase (AChE) was inhibited in vitro by cyclosarin (pH 8.0, 25 °C) and reactivated with 22 different pyridinium-oximes. Only three compounds were shown to be superior to the other oximes: 4-carbamoyl-4´-[(hydroxyimino)methyl]-1,1´-(oxydimethylene)dipyridin-1-ium dichloride (HS-6), 4´-carbamoyl-2-[(hydroxyimino)methyl]-1,1´-(oxydimethylene)dipyridin-1-ium dichloride (HI-6), and 4´-carbamoyl-2-[(hydroxyimino)methyl]-1,1´-(but-2-ene-1,4-diyl)dipyridin-1-ium dichloride (BI-6).
dcterms:title
Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium-oximes Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium-oximes Reaktivace cyklosarinem inhibované acetylcholinesterázy pyridiniovými oximy
skos:prefLabel
Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium-oximes Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium-oximes Reaktivace cyklosarinem inhibované acetylcholinesterázy pyridiniovými oximy
skos:notation
RIV/60162694:G38__/04:00001080!RIV/2005/MO0/G38005/N
n4:strany
39-43
n4:aktivita
n15:P
n4:aktivity
P(ONVLAJEP20031)
n4:cisloPeriodika
1
n4:dodaniDat
n10:2005
n4:domaciTvurceVysledku
n6:5211336 n6:6306888
n4:druhVysledku
n12:J
n4:duvernostUdaju
n17:S
n4:entitaPredkladatele
n9:predkladatel
n4:idSjednocenehoVysledku
583624
n4:idVysledku
RIV/60162694:G38__/04:00001080
n4:jazykVysledku
n13:eng
n4:klicovaSlova
acetylcholinesterase;oxime;reactivation;cyclosarin;in vitro
n4:klicoveSlovo
n7:cyclosarin n7:oxime n7:reactivation n7:in%20vitro n7:acetylcholinesterase
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[C4B9E30C731A]
n4:nazevZdroje
Journal of Enzyme Inhibition and Medicinal Chemistry
n4:obor
n8:FP
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
2
n4:projekt
n18:ONVLAJEP20031
n4:rokUplatneniVysledku
n10:2004
n4:svazekPeriodika
19
n4:tvurceVysledku
Patočka, Jiří Kuča, Kamil
s:issn
8755-5093
s:numberOfPages
5
n14:organizacniJednotka
G38