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Statements

Subject Item
n2:RIV%2F60162694%3AG38__%2F04%3A00001077%21RIV%2F2005%2FMO0%2FG38005%2FN
rdf:type
skos:Concept n18:Vysledek
dcterms:description
The oxime K005 [1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX were tested. Its reactivation potency was not better in comparison with the currently used AChE reactivator - pralidoxime. On the other hand, the oxime K005 has its maximum reactivation ability at the concentration 10-4 M, which could be achieved for human use. The maximum concentration of pralidoxime was reached at the concentrations 10-1 M [for cyclosarin] and 10-3 M [for VX] but these concentrations are not available for the use in vivo. The oxime K005 [1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX were tested. Its reactivation potency was not better in comparison with the currently used AChE reactivator - pralidoxime. On the other hand, the oxime K005 has its maximum reactivation ability at the concentration 10-4 M, which could be achieved for human use. The maximum concentration of pralidoxime was reached at the concentrations 10-1 M [for cyclosarin] and 10-3 M [for VX] but these concentrations are not available for the use in vivo. 1,3-bis(2-hydroxyiminomethylpyridinium) propan jako potenciální reaktivátor acetylcholinesterázy inhibované nervově paralytickými látkami
dcterms:title
1,3-bis(2-hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents 1,3-bis(2-hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents 1,3-bis(2-hydroxyiminomethylpyridinium) propan jako potenciální reaktivátor acetylcholinesterázy inhibované nervově paralytickými látkami
skos:prefLabel
1,3-bis(2-hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents 1,3-bis(2-hydroxyiminomethylpyridinium) propan jako potenciální reaktivátor acetylcholinesterázy inhibované nervově paralytickými látkami 1,3-bis(2-hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents
skos:notation
RIV/60162694:G38__/04:00001077!RIV/2005/MO0/G38005/N
n3:strany
167-169
n3:aktivita
n11:P
n3:aktivity
P(ONVLAJEP20031)
n3:cisloPeriodika
3
n3:dodaniDat
n10:2005
n3:domaciTvurceVysledku
n16:6306888
n3:druhVysledku
n6:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
596503
n3:idVysledku
RIV/60162694:G38__/04:00001077
n3:jazykVysledku
n14:eng
n3:klicovaSlova
acetylcholinesterase;reactivation;inhibition;oximes;reactivator;pralidoxime;cyclosarin;VX;in vitro;K005;nerve agents;organophosphates
n3:klicoveSlovo
n4:in%20vitro n4:pralidoxime n4:acetylcholinesterase n4:nerve%20agents n4:inhibition n4:organophosphates n4:VX n4:K005 n4:reactivation n4:cyclosarin n4:reactivator n4:oximes
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[D87CEB80573F]
n3:nazevZdroje
Acta Medica (Hradec Králové)
n3:obor
n7:FP
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
2
n3:projekt
n9:ONVLAJEP20031
n3:rokUplatneniVysledku
n10:2004
n3:svazekPeriodika
47
n3:tvurceVysledku
Dohnal, Vlastimil Kuča, Kamil
s:issn
1211-4286
s:numberOfPages
3
n12:organizacniJednotka
G38