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Statements

Subject Item
n2:RIV%2F60162694%3AG38__%2F04%3A00001074%21RIV%2F2005%2FMO0%2FG38005%2FN
rdf:type
skos:Concept n12:Vysledek
dcterms:description
A comparison of the efficacy of a bispyridinium oxime - 1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods The efficacy of a bispyridinium oxime 1,4-bis(2-hydroxyiminomethylpyridinium) butane dibromide, called K033, and currently used oximes (pralidoxime, obidoxime, the oxime HI-6) to reactivate acetylcholinesterase inhibited by various nerve agent (sarin, tabun cyclosarin) was tested by in vitro methods. The new oxime K033 was found to be more efficacious reactivator of sarin or cyclosarin-inhibited acetylcholinesterase than pralidoxime and obidoxime but it did not reach the efficacy of the oxime HI-6 in the case of the inhibition of acetylcholinesterase by sarin or cyclosarin. On the other hand, the oxime K033 is more efficacious than the oxime HI-6 to reactivate tabun-inhibited acetylcholinesterase. Thus, the oxime K033 seems to be relatively efficacious broad spectrum acetylcholinesterase reactivator and, therefore, it could be useful if no information about the type of nerve agent used is available. The efficacy of a bispyridinium oxime 1,4-bis(2-hydroxyiminomethylpyridinium) butane dibromide, called K033, and currently used oximes (pralidoxime, obidoxime, the oxime HI-6) to reactivate acetylcholinesterase inhibited by various nerve agent (sarin, tabun cyclosarin) was tested by in vitro methods. The new oxime K033 was found to be more efficacious reactivator of sarin or cyclosarin-inhibited acetylcholinesterase than pralidoxime and obidoxime but it did not reach the efficacy of the oxime HI-6 in the case of the inhibition of acetylcholinesterase by sarin or cyclosarin. On the other hand, the oxime K033 is more efficacious than the oxime HI-6 to reactivate tabun-inhibited acetylcholinesterase. Thus, the oxime K033 seems to be relatively efficacious broad spectrum acetylcholinesterase reactivator and, therefore, it could be useful if no information about the type of nerve agent used is available.
dcterms:title
A comparison of the efficacy of a bispyridinium oxime - 1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods A comparison of the efficacy of a bispyridinium oxime - 1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods A comparison of the efficacy of a bispyridinium oxime - 1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods
skos:prefLabel
A comparison of the efficacy of a bispyridinium oxime - 1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods A comparison of the efficacy of a bispyridinium oxime - 1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods A comparison of the efficacy of a bispyridinium oxime - 1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods
skos:notation
RIV/60162694:G38__/04:00001074!RIV/2005/MO0/G38005/N
n3:strany
795-798
n3:aktivita
n11:P
n3:aktivity
P(OBVLAJEP20032)
n3:cisloPeriodika
10
n3:dodaniDat
n8:2005
n3:domaciTvurceVysledku
n16:6306888 n16:2182262 n16:3691314
n3:druhVysledku
n13:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
552861
n3:idVysledku
RIV/60162694:G38__/04:00001074
n3:jazykVysledku
n9:eng
n3:klicovaSlova
acetylcholinesterase;reactivation;K033;sarin;tabun;cyclosarin
n3:klicoveSlovo
n4:acetylcholinesterase n4:reactivation n4:sarin n4:cyclosarin n4:tabun n4:K033
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[C478EC8C7338]
n3:nazevZdroje
Pharmazie
n3:obor
n5:FP
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:projekt
n14:OBVLAJEP20032
n3:rokUplatneniVysledku
n8:2004
n3:svazekPeriodika
59
n3:tvurceVysledku
Kuča, Kamil Kassa, Jiří Cabal, Jiří
s:issn
0031-7144
s:numberOfPages
4
n17:organizacniJednotka
G38