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Statements

Subject Item
n2:RIV%2F60077344%3A_____%2F14%3A00436590%21RIV15-AV0-60077344
rdf:type
skos:Concept n15:Vysledek
dcterms:description
Continuous human exploitation of environmental resources and an increase in human outdoor activities have led to more contact with arthropod vectors, promoting an emergence and resurgence of tick-borne pathogens. Clinical trials of cetuximab,1 a monoclonal antibody that inhibits epidermal growth factor receptor used for treatment of metastatic colorectal cancer, have shown that the drug produces more hypersensitivity than expected, with some fatal cases.2 Patients who developed these hypersensitivity reactions were deemed to have pre-existing IgE antibodies specifi c to the alpha-gal present in the variable portion of cetuximab.3 Continuous human exploitation of environmental resources and an increase in human outdoor activities have led to more contact with arthropod vectors, promoting an emergence and resurgence of tick-borne pathogens. Clinical trials of cetuximab,1 a monoclonal antibody that inhibits epidermal growth factor receptor used for treatment of metastatic colorectal cancer, have shown that the drug produces more hypersensitivity than expected, with some fatal cases.2 Patients who developed these hypersensitivity reactions were deemed to have pre-existing IgE antibodies specifi c to the alpha-gal present in the variable portion of cetuximab.3
dcterms:title
Cancer research meets tick vectors for infectious diseases Cancer research meets tick vectors for infectious diseases
skos:prefLabel
Cancer research meets tick vectors for infectious diseases Cancer research meets tick vectors for infectious diseases
skos:notation
RIV/60077344:_____/14:00436590!RIV15-AV0-60077344
n3:aktivita
n11:I
n3:aktivity
I
n3:cisloPeriodika
10
n3:dodaniDat
n14:2015
n3:domaciTvurceVysledku
Valdés, James J.
n3:druhVysledku
n6:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
6146
n3:idVysledku
RIV/60077344:_____/14:00436590
n3:jazykVysledku
n8:eng
n3:klicovaSlova
protective immunity; IgE; responses; mice
n3:klicoveSlovo
n4:mice n4:responses n4:protective%20immunity n4:IgE
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[67D1FF348587]
n3:nazevZdroje
Lancet Infectious Diseases
n3:obor
n10:EC
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
3
n3:rokUplatneniVysledku
n14:2014
n3:svazekPeriodika
14
n3:tvurceVysledku
Cabezas-Cruz, A. de la Fuente, J. Valdés, James J.
n3:wos
000342249600012
s:issn
1473-3099
s:numberOfPages
2
n16:doi
10.1016/S1473-3099(14)70902-8