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Statements

Subject Item
n2:RIV%2F60077344%3A_____%2F14%3A00435095%21RIV15-GA0-60077344
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Previously, scientists sometimes resorted to infecting themselves or colleagues with parasites, usually to assess the pathogenicity and obtain insight into the life cycles of the parasites, host specificity, and epidemiology. However, with recent research addressing the possible beneficial impact of intestinal helminths on a range of immune-mediated diseases in humans, these studies offer valuable information, although many are now considered unethical owing to a lack of experimental oversight and informed consent. Here, we critically review cases in which humans were deliberately infected with parasites. Moreover, we summarize the contribution of (self-) infections and propose protist and helminth candidates, chosen on the basis of several criteria, to test as possible therapy for selected human diseases. Previously, scientists sometimes resorted to infecting themselves or colleagues with parasites, usually to assess the pathogenicity and obtain insight into the life cycles of the parasites, host specificity, and epidemiology. However, with recent research addressing the possible beneficial impact of intestinal helminths on a range of immune-mediated diseases in humans, these studies offer valuable information, although many are now considered unethical owing to a lack of experimental oversight and informed consent. Here, we critically review cases in which humans were deliberately infected with parasites. Moreover, we summarize the contribution of (self-) infections and propose protist and helminth candidates, chosen on the basis of several criteria, to test as possible therapy for selected human diseases.
dcterms:title
(Self-) infections with parasites: re-interpretations for the present (Self-) infections with parasites: re-interpretations for the present
skos:prefLabel
(Self-) infections with parasites: re-interpretations for the present (Self-) infections with parasites: re-interpretations for the present
skos:notation
RIV/60077344:_____/14:00435095!RIV15-GA0-60077344
n3:aktivita
n13:P n13:I
n3:aktivity
I, P(GAP506/12/1632)
n3:cisloPeriodika
8
n3:dodaniDat
n9:2015
n3:domaciTvurceVysledku
n6:8531498 n6:6284035 n6:7130570 n6:1369490
n3:druhVysledku
n10:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
44315
n3:idVysledku
RIV/60077344:_____/14:00435095
n3:jazykVysledku
n11:eng
n3:klicovaSlova
self-infection; volunteers; protists; helminths; autoimmune diseases; helminth therapy
n3:klicoveSlovo
n4:volunteers n4:autoimmune%20diseases n4:self-infection n4:helminth%20therapy n4:helminths n4:protists
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[F8597DCB83C2]
n3:nazevZdroje
Trends in Parasitology
n3:obor
n5:EG
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n18:GAP506%2F12%2F1632
n3:rokUplatneniVysledku
n9:2014
n3:svazekPeriodika
30
n3:tvurceVysledku
Kuchta, Roman Scholz, Tomáš Lukeš, Julius Pomajbíková, Kateřina
n3:wos
000340305300004
s:issn
1471-4922
s:numberOfPages
9
n14:doi
10.1016/j.pt.2014.06.005