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Statements

Subject Item
n2:RIV%2F60077344%3A_____%2F13%3A00397476%21RIV14-AV0-60077344
rdf:type
skos:Concept n17:Vysledek
dcterms:description
The genomes of microsporidia in the genus Encephalitozoon have been extensively studied for their minimalistic features, but they have seldom been used to investigate basic characteristics of the biology of these organisms, such as their ploidy or their mode of reproduction. In the present study, we aimed to tackle this issue by mapping Illumina sequence reads against the genomes of four strains of E. cuniculi. This approach, combined with more conventional molecular biology techniques, resulted in the identification of heterozygosity in all strains investigated, a typical signature of a diploid nuclear state. In sharp contrast with similar studies recently performed on a distant microsporidian lineage (Nematocida spp.), the level of heterozygosity that we identified across the E. cuniculi genomes was found to be extremely low. This reductive intraindividual genetic variation could result from the long-term propagation of these strains under laboratory conditions, but we propose that it could also reflect an intrinsic capacity of these vertebrate pathogens to self-reproduce. The genomes of microsporidia in the genus Encephalitozoon have been extensively studied for their minimalistic features, but they have seldom been used to investigate basic characteristics of the biology of these organisms, such as their ploidy or their mode of reproduction. In the present study, we aimed to tackle this issue by mapping Illumina sequence reads against the genomes of four strains of E. cuniculi. This approach, combined with more conventional molecular biology techniques, resulted in the identification of heterozygosity in all strains investigated, a typical signature of a diploid nuclear state. In sharp contrast with similar studies recently performed on a distant microsporidian lineage (Nematocida spp.), the level of heterozygosity that we identified across the E. cuniculi genomes was found to be extremely low. This reductive intraindividual genetic variation could result from the long-term propagation of these strains under laboratory conditions, but we propose that it could also reflect an intrinsic capacity of these vertebrate pathogens to self-reproduce.
dcterms:title
Extremely Reduced Levels of Heterozygosity in the Vertebrate Pathogen Encephalitozoon cuniculi Extremely Reduced Levels of Heterozygosity in the Vertebrate Pathogen Encephalitozoon cuniculi
skos:prefLabel
Extremely Reduced Levels of Heterozygosity in the Vertebrate Pathogen Encephalitozoon cuniculi Extremely Reduced Levels of Heterozygosity in the Vertebrate Pathogen Encephalitozoon cuniculi
skos:notation
RIV/60077344:_____/13:00397476!RIV14-AV0-60077344
n17:predkladatel
n18:ico%3A60077344
n3:aktivita
n10:P n10:I
n3:aktivity
I, P(GAP505/11/1163)
n3:cisloPeriodika
4
n3:dodaniDat
n9:2014
n3:domaciTvurceVysledku
n4:8524777 n4:4228677
n3:druhVysledku
n8:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
74455
n3:idVysledku
RIV/60077344:_____/13:00397476
n3:jazykVysledku
n19:eng
n3:klicovaSlova
intracellular parasites; microsporidian genome; sexual reproduction; clonal diploids
n3:klicoveSlovo
n5:intracellular%20parasites n5:clonal%20diploids n5:sexual%20reproduction n5:microsporidian%20genome
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[A5C89EF4663D]
n3:nazevZdroje
Eukaryotic Cell
n3:obor
n15:EB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
6
n3:projekt
n14:GAP505%2F11%2F1163
n3:rokUplatneniVysledku
n9:2013
n3:svazekPeriodika
12
n3:tvurceVysledku
Weiss, L. M. Corradi, N. Farinelli, L. Sak, Bohumil Kváč, Martin Selman, M.
n3:wos
000316805100003
s:issn
1535-9778
s:numberOfPages
7
n16:doi
10.1128/EC.00307-12