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Statements

Subject Item
n2:RIV%2F60077344%3A_____%2F13%3A00396406%21RIV14-AV0-60077344
rdf:type
skos:Concept n6:Vysledek
dcterms:description
Obesity is characterised by a chronic state of low-grade inflammation in different tissues including the vasculature. There is a causal link between adipose tissue (AT) inflammation and obesity-related metabolic complications, such as the development of insulin resistance and subsequently of type 2 diabetes. Intense efforts in the recent years have aimed at dissecting the pathophysiology of AT inflammation. The role of both innate and adaptive immune cells, such as macrophages or cytotoxic T cells in AT inflammation has been demonstrated. Besides these cells, more leukocyte subpopulations have been recently implicated in obesity, including neutrophils and eosinophils, mast cells, natural killer cells or dendritic cells. The involvement of multiple leukocyte subpopulations underlines the complexity of obesity-associated AT inflammation. In this review, we discuss the role of innate immune cells in AT inflammation, obesity and related metabolic disorders. Obesity is characterised by a chronic state of low-grade inflammation in different tissues including the vasculature. There is a causal link between adipose tissue (AT) inflammation and obesity-related metabolic complications, such as the development of insulin resistance and subsequently of type 2 diabetes. Intense efforts in the recent years have aimed at dissecting the pathophysiology of AT inflammation. The role of both innate and adaptive immune cells, such as macrophages or cytotoxic T cells in AT inflammation has been demonstrated. Besides these cells, more leukocyte subpopulations have been recently implicated in obesity, including neutrophils and eosinophils, mast cells, natural killer cells or dendritic cells. The involvement of multiple leukocyte subpopulations underlines the complexity of obesity-associated AT inflammation. In this review, we discuss the role of innate immune cells in AT inflammation, obesity and related metabolic disorders.
dcterms:title
The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance
skos:prefLabel
The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance
skos:notation
RIV/60077344:_____/13:00396406!RIV14-AV0-60077344
n6:predkladatel
n7:ico%3A60077344
n3:aktivita
n14:I
n3:aktivity
I
n3:cisloPeriodika
3
n3:dodaniDat
n10:2014
n3:domaciTvurceVysledku
n11:5799864
n3:druhVysledku
n17:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
103325
n3:idVysledku
RIV/60077344:_____/13:00396406
n3:jazykVysledku
n16:eng
n3:klicovaSlova
Obesity; adipose tissue; inflammation; review; leukocytes
n3:klicoveSlovo
n8:Obesity n8:leukocytes n8:review n8:adipose%20tissue n8:inflammation
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[735B2B00A3CC]
n3:nazevZdroje
Thrombosis and Haemostasis
n3:obor
n9:EC
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
3
n3:rokUplatneniVysledku
n10:2013
n3:svazekPeriodika
109
n3:tvurceVysledku
Chung, K.-J. Chmelař, Jindřich Chavakis, T.
n3:wos
000316164200007
s:issn
0340-6245
s:numberOfPages
8
n15:doi
10.1160/TH12-09-0703