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Statements

Subject Item
n2:RIV%2F60077344%3A_____%2F13%3A00390569%21RIV14-AV0-60077344
rdf:type
n13:Vysledek skos:Concept
dcterms:description
Telomeres are essential nucleoprotein structures at the ends of eukaryotic chromosomes. They play several essential roles preserving genome stability and function. In the absence of special telomere maintenance mechanisms telomeres shorten with every round of DNA replication. The telomere shortening leads to replicative senescence and apoptosis. Several telomere maintenance mechanisms have been identified; these are reflected in several known types of telomeres. In most eukaryotes telomeres comprise a tandem array of a short, 5-8 bp, well conserved repeat unit, and telomere length is maintained by telomerase, a specialized reverse transcriptase that carries its own RNA template and adds telomeric sequences onto chromosome ends. Nevertheless, in some organisms the array of short telomeric sequence motifs has been replaced with less conventional sequences, such as satellite sequences or transposable elements. Telomeres are essential nucleoprotein structures at the ends of eukaryotic chromosomes. They play several essential roles preserving genome stability and function. In the absence of special telomere maintenance mechanisms telomeres shorten with every round of DNA replication. The telomere shortening leads to replicative senescence and apoptosis. Several telomere maintenance mechanisms have been identified; these are reflected in several known types of telomeres. In most eukaryotes telomeres comprise a tandem array of a short, 5-8 bp, well conserved repeat unit, and telomere length is maintained by telomerase, a specialized reverse transcriptase that carries its own RNA template and adds telomeric sequences onto chromosome ends. Nevertheless, in some organisms the array of short telomeric sequence motifs has been replaced with less conventional sequences, such as satellite sequences or transposable elements.
dcterms:title
Telomeres: Their structure and maintenance Telomeres: Their structure and maintenance
skos:prefLabel
Telomeres: Their structure and maintenance Telomeres: Their structure and maintenance
skos:notation
RIV/60077344:_____/13:00390569!RIV14-AV0-60077344
n13:predkladatel
n21:ico%3A60077344
n3:aktivita
n9:P n9:I
n3:aktivity
I, P(GAP501/10/1215)
n3:dodaniDat
n11:2014
n3:domaciTvurceVysledku
n14:1678507
n3:druhVysledku
n18:C
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
110231
n3:idVysledku
RIV/60077344:_____/13:00390569
n3:jazykVysledku
n19:eng
n3:klicovaSlova
telomeric DNA
n3:klicoveSlovo
n6:telomeric%20DNA
n3:kontrolniKodProRIV
[6B041AFA31BB]
n3:mistoVydani
Rijeka
n3:nazevZdroje
The Mechanisms of DNA Replication
n3:obor
n8:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetStranKnihy
611
n3:pocetTvurcuVysledku
2
n3:projekt
n4:GAP501%2F10%2F1215
n3:rokUplatneniVysledku
n11:2013
n3:tvurceVysledku
Čapková Frydrychová, Radmila Mason, J. M.
s:numberOfPages
21
n10:doi
10.5772/51356
n12:hasPublisher
InTech, Open Access Publisher
n20:isbn
978-953-51-0991-4