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Statements

Subject Item
n2:RIV%2F60077344%3A_____%2F13%3A00388970%21RIV14-AV0-60077344
rdf:type
n4:Vysledek skos:Concept
rdfs:seeAlso
http://www.mdpi.com/1422-0067/14/2/3026
dcterms:description
Circadian rhythms are found in almost all organisms from cyanobacteria to humans, where most behavioral and physiological processes occur over a period of approximately 24 h in tandem with the day/night cycles. The role of circadian clocks in regulating metabolism and consequently cellular and metabolic homeostasis is an intensively investigated area of research. A fully functional circadian clock would be vital to timing events in general metabolism, thus contributing to metabolic health and to ensure an increased “health-span during the process of aging. Here, we present recent evidence of links between clocks, cellular metabolism, aging and oxidative stress. In the light of these data, we arrive at conceptual generalizations of this relationship across the spectrum of model organisms from fruit flies to mammals. Circadian rhythms are found in almost all organisms from cyanobacteria to humans, where most behavioral and physiological processes occur over a period of approximately 24 h in tandem with the day/night cycles. The role of circadian clocks in regulating metabolism and consequently cellular and metabolic homeostasis is an intensively investigated area of research. A fully functional circadian clock would be vital to timing events in general metabolism, thus contributing to metabolic health and to ensure an increased “health-span during the process of aging. Here, we present recent evidence of links between clocks, cellular metabolism, aging and oxidative stress. In the light of these data, we arrive at conceptual generalizations of this relationship across the spectrum of model organisms from fruit flies to mammals.
dcterms:title
Nature’s timepiece – molecular coordination of metabolism and impact on aging Nature’s timepiece – molecular coordination of metabolism and impact on aging
skos:prefLabel
Nature’s timepiece – molecular coordination of metabolism and impact on aging Nature’s timepiece – molecular coordination of metabolism and impact on aging
skos:notation
RIV/60077344:_____/13:00388970!RIV14-AV0-60077344
n4:predkladatel
n13:ico%3A60077344
n3:aktivita
n14:I n14:P
n3:aktivity
I, P(GAP501/10/1215)
n3:cisloPeriodika
2
n3:dodaniDat
n15:2014
n3:domaciTvurceVysledku
n11:9631631 n11:4230930
n3:druhVysledku
n9:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
90864
n3:idVysledku
RIV/60077344:_____/13:00388970
n3:jazykVysledku
n10:eng
n3:klicovaSlova
aging; circadian clocks; cellular metabolism
n3:klicoveSlovo
n12:aging n12:circadian%20clocks n12:cellular%20metabolism
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[64460BADD0EC]
n3:nazevZdroje
International Journal of Molecular Sciences
n3:obor
n19:ED
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
3
n3:projekt
n18:GAP501%2F10%2F1215
n3:rokUplatneniVysledku
n15:2013
n3:svazekPeriodika
14
n3:tvurceVysledku
Bednářová, Andrea Krishnan, N. Kodrík, Dalibor
n3:wos
000315397900045
s:issn
1422-0067
s:numberOfPages
24
n20:doi
10.3390/ijms14023026