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Statements

Subject Item
n2:RIV%2F60077344%3A_____%2F12%3A00387477%21RIV13-GA0-60077344
rdf:type
n8:Vysledek skos:Concept
rdfs:seeAlso
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3024.2012.01375.x/abstract
dcterms:description
Dendritic cells are a sentinel in defending against pathogens and tick saliva facilitates transmission of tick-borne pathogens by modulating the host immune response. The maturation of dendritic cells is inhibited by tick saliva. To elucidate the mechanism of this inhibition, we tested the impact of Ixodes ricinus tick saliva on signalling pathways activated by Toll-like receptor (TLR-2) ligand and Borrelia afzelii in spleen dendritic cells. The activation of nuclear factor-jB (NF-jB) p65 and phosphatidylinositol-3 kinase (PI3K)/ Akt pathways was decreased by tick saliva upon both TLR- 2 and Borrelia stimulation. Among the mitogen-activated protein kinases (MAPK), the activation of extracellular matrix-regulated kinase (Erk1/ 2) was suppressed by tick saliva, but not p38. In response to spirochaetes, the amount of TNF-a decreased in the presence of tick saliva which was mediated by selective suppression of Erk1/ 2, NF-jB and Akt as tick saliva mimicked the effect of their specific inhibitors, UO126, IKK-IV and LY294002, respectively. Saliva- induced enhancement of IL-10 was not observed in the presence of specific inhibitor of Protein Kinase A (PKA), H-89, suggesting the involvement of PKA pathway in IL-10 production. Our cumulative data show that tick saliva interferes with several signalling pathways, thus modulating the immune functions of dendritic cells. Dendritic cells are a sentinel in defending against pathogens and tick saliva facilitates transmission of tick-borne pathogens by modulating the host immune response. The maturation of dendritic cells is inhibited by tick saliva. To elucidate the mechanism of this inhibition, we tested the impact of Ixodes ricinus tick saliva on signalling pathways activated by Toll-like receptor (TLR-2) ligand and Borrelia afzelii in spleen dendritic cells. The activation of nuclear factor-jB (NF-jB) p65 and phosphatidylinositol-3 kinase (PI3K)/ Akt pathways was decreased by tick saliva upon both TLR- 2 and Borrelia stimulation. Among the mitogen-activated protein kinases (MAPK), the activation of extracellular matrix-regulated kinase (Erk1/ 2) was suppressed by tick saliva, but not p38. In response to spirochaetes, the amount of TNF-a decreased in the presence of tick saliva which was mediated by selective suppression of Erk1/ 2, NF-jB and Akt as tick saliva mimicked the effect of their specific inhibitors, UO126, IKK-IV and LY294002, respectively. Saliva- induced enhancement of IL-10 was not observed in the presence of specific inhibitor of Protein Kinase A (PKA), H-89, suggesting the involvement of PKA pathway in IL-10 production. Our cumulative data show that tick saliva interferes with several signalling pathways, thus modulating the immune functions of dendritic cells.
dcterms:title
Effect of tick saliva on signalling pathways activated by TLR-2 ligand and Borrelia afzelii in dendritic cells Effect of tick saliva on signalling pathways activated by TLR-2 ligand and Borrelia afzelii in dendritic cells
skos:prefLabel
Effect of tick saliva on signalling pathways activated by TLR-2 ligand and Borrelia afzelii in dendritic cells Effect of tick saliva on signalling pathways activated by TLR-2 ligand and Borrelia afzelii in dendritic cells
skos:notation
RIV/60077344:_____/12:00387477!RIV13-GA0-60077344
n8:predkladatel
n9:ico%3A60077344
n3:aktivita
n5:P n5:I
n3:aktivity
I, P(GAP302/12/2208), P(LC06009)
n3:cisloPeriodika
8-9
n3:dodaniDat
n16:2013
n3:domaciTvurceVysledku
n6:6178529 n6:6204953
n3:druhVysledku
n19:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
133341
n3:idVysledku
RIV/60077344:_____/12:00387477
n3:jazykVysledku
n12:eng
n3:klicovaSlova
Borrelia; dendritic cells; tick saliva; Toll-like receptor signalling
n3:klicoveSlovo
n14:Toll-like%20receptor%20signalling n14:Borrelia n14:dendritic%20cells n14:tick%20saliva
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[6817393749C4]
n3:nazevZdroje
Parasite immunology
n3:obor
n11:EC
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:projekt
n10:GAP302%2F12%2F2208 n10:LC06009
n3:rokUplatneniVysledku
n16:2012
n3:svazekPeriodika
35
n3:tvurceVysledku
Lieskovská, Jaroslava Kopecký, Jan
n3:wos
000307105500004
s:issn
0141-9838
s:numberOfPages
9
n15:doi
10.1111/j.1365-3024.2011.01345.x