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Statements

Subject Item
n2:RIV%2F60077344%3A_____%2F12%3A00377104%21RIV13-AV0-60077344
rdf:type
skos:Concept n9:Vysledek
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/S0020751912000033
dcterms:description
The objectives of this study were to identify Rhipicephalus annulatus genes differentially expressed in response to infection with Babesia bigemina. Functional analyses were conducted on selected genes by RNA interference in both R. annulatus and R. microplus ticks. 800 randomly selected suppression-subtractive hybridisation library clones were sequenced and analysed. Differentially expressed genes with putative functions in tick-pathogen interactions were selected for validation of SSH results by real-time reverse transcription-PCR. Genes encoding for TROSPA, calreticulin, ricinusin and serum amyloid A were over-expressed in B. bigemina-infected ticks while Kunitz-type protease inhibitor 5 mRNA levels were down-regulated in infected ticks. Functional analysis of differentially expressed genes by dsRNA-mediated RNAi showed that under the conditions of the present study knockdown of TROSPA and serum amyloid A significantly reduced B. bigemina infection levels in R. annulatus. The objectives of this study were to identify Rhipicephalus annulatus genes differentially expressed in response to infection with Babesia bigemina. Functional analyses were conducted on selected genes by RNA interference in both R. annulatus and R. microplus ticks. 800 randomly selected suppression-subtractive hybridisation library clones were sequenced and analysed. Differentially expressed genes with putative functions in tick-pathogen interactions were selected for validation of SSH results by real-time reverse transcription-PCR. Genes encoding for TROSPA, calreticulin, ricinusin and serum amyloid A were over-expressed in B. bigemina-infected ticks while Kunitz-type protease inhibitor 5 mRNA levels were down-regulated in infected ticks. Functional analysis of differentially expressed genes by dsRNA-mediated RNAi showed that under the conditions of the present study knockdown of TROSPA and serum amyloid A significantly reduced B. bigemina infection levels in R. annulatus.
dcterms:title
Functional genomics studies of Rhipicephalus (Boophilus) annulatus ticks in response to infection with the cattle protozoan parasite, Babesia bigemina Functional genomics studies of Rhipicephalus (Boophilus) annulatus ticks in response to infection with the cattle protozoan parasite, Babesia bigemina
skos:prefLabel
Functional genomics studies of Rhipicephalus (Boophilus) annulatus ticks in response to infection with the cattle protozoan parasite, Babesia bigemina Functional genomics studies of Rhipicephalus (Boophilus) annulatus ticks in response to infection with the cattle protozoan parasite, Babesia bigemina
skos:notation
RIV/60077344:_____/12:00377104!RIV13-AV0-60077344
n9:predkladatel
n10:ico%3A60077344
n3:aktivita
n6:Z
n3:aktivity
Z(AV0Z60220518)
n3:cisloPeriodika
2
n3:dodaniDat
n15:2013
n3:domaciTvurceVysledku
n7:2937204 n7:5005116 n7:9286357
n3:druhVysledku
n11:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
137379
n3:idVysledku
RIV/60077344:_____/12:00377104
n3:jazykVysledku
n19:eng
n3:klicovaSlova
Tick; Genomics; Babesia; Rhipicephalus; Boophilus; RNA interference; Vaccine
n3:klicoveSlovo
n13:Boophilus n13:Babesia n13:Tick n13:Rhipicephalus n13:Vaccine n13:RNA%20interference n13:Genomics
n3:kodStatuVydavatele
AU - Australské společenství
n3:kontrolniKodProRIV
[7DE12DC54033]
n3:nazevZdroje
International Journal for Parasitology
n3:obor
n17:EC
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
10
n3:rokUplatneniVysledku
n15:2012
n3:svazekPeriodika
42
n3:tvurceVysledku
Golovchenko, Maryna Rudenko, Natalia Domingos, A. Almazán, C. do Rosário, A. Antunes, S. Galindo, R. C. Grubhoffer, Libor de la Fuente, J. Shkap, V.
n3:wos
000301820000007
n3:zamer
n20:AV0Z60220518
s:issn
0020-7519
s:numberOfPages
9
n14:doi
10.1016/j.ijpara.2011.12.003