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Statements

Subject Item
n2:RIV%2F60077344%3A_____%2F12%3A00375992%21RIV13-AV0-60077344
rdf:type
skos:Concept n5:Vysledek
dcterms:description
Type I interferons (IFN-a and IFN-beta) are crucial determinants of the host immune response and tick saliva modulates this response, thus facilitating the transmission of tickborne pathogens. The current study therefore examines the effect of Ixodes ricinus tick saliva on IFN-beta signalling in murine dendritic cells using lipopolysaccharide (LPS) and Borrelia afzelii spirochaetes as inducers. Our results show that Borrelia-induced activation of STAT-1 was suppressed by tick saliva. Our data indicate that similar to I. ricinus tick saliva may modulate the host immune response by attenuating the initial signal transduction pathway of type I IFN. Type I interferons (IFN-a and IFN-beta) are crucial determinants of the host immune response and tick saliva modulates this response, thus facilitating the transmission of tickborne pathogens. The current study therefore examines the effect of Ixodes ricinus tick saliva on IFN-beta signalling in murine dendritic cells using lipopolysaccharide (LPS) and Borrelia afzelii spirochaetes as inducers. Our results show that Borrelia-induced activation of STAT-1 was suppressed by tick saliva. Our data indicate that similar to I. ricinus tick saliva may modulate the host immune response by attenuating the initial signal transduction pathway of type I IFN.
dcterms:title
Tick saliva suppresses IFN signalling in dendritic cells upon Borrelia afzelii infection Tick saliva suppresses IFN signalling in dendritic cells upon Borrelia afzelii infection
skos:prefLabel
Tick saliva suppresses IFN signalling in dendritic cells upon Borrelia afzelii infection Tick saliva suppresses IFN signalling in dendritic cells upon Borrelia afzelii infection
skos:notation
RIV/60077344:_____/12:00375992!RIV13-AV0-60077344
n5:predkladatel
n6:ico%3A60077344
n3:aktivita
n10:P n10:I
n3:aktivity
I, P(LC06009)
n3:cisloPeriodika
1
n3:dodaniDat
n15:2013
n3:domaciTvurceVysledku
n8:6178529 n8:6204953
n3:druhVysledku
n7:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
174427
n3:idVysledku
RIV/60077344:_____/12:00375992
n3:jazykVysledku
n18:eng
n3:klicovaSlova
Borrelia; dendritic cells; interferon signalling; tick saliva
n3:klicoveSlovo
n12:Borrelia n12:interferon%20signalling n12:tick%20saliva n12:dendritic%20cells
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[37D82870C073]
n3:nazevZdroje
Parasite immunology
n3:obor
n17:EC
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:projekt
n9:LC06009
n3:rokUplatneniVysledku
n15:2012
n3:svazekPeriodika
34
n3:tvurceVysledku
Kopecký, Jan Lieskovská, Jaroslava
n3:wos
000298594000005
s:issn
0141-9838
s:numberOfPages
8
n19:doi
10.1111/j.1365-3024.2011.01345.x