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Statements

Subject Item
n2:RIV%2F60077344%3A_____%2F11%3A00364291%21RIV12-AV0-60077344
rdf:type
n6:Vysledek skos:Concept
dcterms:description
Most eukaryotes elongate chromosome ends with telomerase that repeatedly adds copies of the short telomeric DNA sequence to the chromosome end. While there is strict conservation of telomeric sequence repeat in most species, the repeat unit has changed over evolutionary time. Lack of the predominant telomeric sequence in a species does not, however, signify that telomerase-generated terminal sequences are missing. Conversely, the presence of a canonical telomeric sequence does not necessarily indicate telomerase as a telomere maintenance mechanism. Although telomerase may have been the mechanism of telomere maintenance of the last common eukaryotic ancestor, it is not the only mechanism used to maintain chromosome length. Telomerase has been lost a few times in the evolution of plants and animals. During insect evolution, for example, telomerase has been lost at least six times. Here, we discuss telomere maintenance mechanisms that replaced telomerase in telomere length maintenance. Most eukaryotes elongate chromosome ends with telomerase that repeatedly adds copies of the short telomeric DNA sequence to the chromosome end. While there is strict conservation of telomeric sequence repeat in most species, the repeat unit has changed over evolutionary time. Lack of the predominant telomeric sequence in a species does not, however, signify that telomerase-generated terminal sequences are missing. Conversely, the presence of a canonical telomeric sequence does not necessarily indicate telomerase as a telomere maintenance mechanism. Although telomerase may have been the mechanism of telomere maintenance of the last common eukaryotic ancestor, it is not the only mechanism used to maintain chromosome length. Telomerase has been lost a few times in the evolution of plants and animals. During insect evolution, for example, telomerase has been lost at least six times. Here, we discuss telomere maintenance mechanisms that replaced telomerase in telomere length maintenance.
dcterms:title
Telomore maintenance on organisms without telomerase Telomore maintenance on organisms without telomerase
skos:prefLabel
Telomore maintenance on organisms without telomerase Telomore maintenance on organisms without telomerase
skos:notation
RIV/60077344:_____/11:00364291!RIV12-AV0-60077344
n6:predkladatel
n7:ico%3A60077344
n4:aktivita
n19:Z
n4:aktivity
Z(AV0Z50070508)
n4:dodaniDat
n5:2012
n4:domaciTvurceVysledku
n17:1678507
n4:druhVysledku
n15:C
n4:duvernostUdaju
n12:S
n4:entitaPredkladatele
n9:predkladatel
n4:idSjednocenehoVysledku
234573
n4:idVysledku
RIV/60077344:_____/11:00364291
n4:jazykVysledku
n16:eng
n4:klicovaSlova
telomere
n4:klicoveSlovo
n11:telomere
n4:kontrolniKodProRIV
[ED493C41EC6D]
n4:mistoVydani
Rijeka
n4:nazevZdroje
DNA Replication-Current Advances
n4:obor
n13:EB
n4:pocetDomacichTvurcuVysledku
1
n4:pocetStranKnihy
694
n4:pocetTvurcuVysledku
3
n4:rokUplatneniVysledku
n5:2011
n4:tvurceVysledku
Mason, J. M. Reddy, H. M. Čapková Frydrychová, Radmila
n4:zamer
n18:AV0Z50070508
s:numberOfPages
24
n8:hasPublisher
InTech
n10:isbn
978-953-307-593-8