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Statements

Subject Item
n2:RIV%2F60077344%3A_____%2F10%3A00352618%21RIV11-AV0-60077344
rdf:type
skos:Concept n6:Vysledek
dcterms:description
The recombinant form of a highly immunogenic 14.6 kDa protein in Triatoma infestans saliva (rTiSP14.6) is a potential epidemiological marker for the detection of triatomine bug populations using IgG responses in peridomestic chickens. However, the persistence of the IgG response prevents it being of value for several months in areas where triatomine control programmes have been implemented. In this investigation, IgM-antibody reactions to crude salivary antigens or rTiSP14.6 decayed rapidly after exposure of chickens and were measurable for only 18 days after a single challenge with T. infestans. In serial exposure experiments, chickens from low and high exposure groups showed no significant differences in anti-saliva and anti-rTiSP14.6 IgM-antibody titres. Highly immunogenic salivary antigens of 12 and 14 kDa were recognised by all chicken sera. The recombinant form of a highly immunogenic 14.6 kDa protein in Triatoma infestans saliva (rTiSP14.6) is a potential epidemiological marker for the detection of triatomine bug populations using IgG responses in peridomestic chickens. However, the persistence of the IgG response prevents it being of value for several months in areas where triatomine control programmes have been implemented. In this investigation, IgM-antibody reactions to crude salivary antigens or rTiSP14.6 decayed rapidly after exposure of chickens and were measurable for only 18 days after a single challenge with T. infestans. In serial exposure experiments, chickens from low and high exposure groups showed no significant differences in anti-saliva and anti-rTiSP14.6 IgM-antibody titres. Highly immunogenic salivary antigens of 12 and 14 kDa were recognised by all chicken sera.
dcterms:title
IgM-antibody responses of chickens to salivary antigens of Triatoma infestans as early biomarkers for low-level infestation of triatomines IgM-antibody responses of chickens to salivary antigens of Triatoma infestans as early biomarkers for low-level infestation of triatomines
skos:prefLabel
IgM-antibody responses of chickens to salivary antigens of Triatoma infestans as early biomarkers for low-level infestation of triatomines IgM-antibody responses of chickens to salivary antigens of Triatoma infestans as early biomarkers for low-level infestation of triatomines
skos:notation
RIV/60077344:_____/10:00352618!RIV11-AV0-60077344
n3:aktivita
n16:Z
n3:aktivity
Z(AV0Z60220518)
n3:cisloPeriodika
11
n3:dodaniDat
n9:2011
n3:domaciTvurceVysledku
Schwarz, Alexandra
n3:druhVysledku
n13:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
262817
n3:idVysledku
RIV/60077344:_____/10:00352618
n3:jazykVysledku
n8:eng
n3:klicovaSlova
antibody response; Chagas disease; chickens; IgM; recombinant protein; salivary proteins; surveillance; Triatoma infestans
n3:klicoveSlovo
n4:salivary%20proteins n4:antibody%20response n4:IgM n4:surveillance n4:recombinant%20protein n4:Chagas%20disease n4:chickens n4:Triatoma%20infestans
n3:kodStatuVydavatele
AU - Australské společenství
n3:kontrolniKodProRIV
[6D632A9C9E1B]
n3:nazevZdroje
International Journal for Parasitology
n3:obor
n12:EC
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n9:2010
n3:svazekPeriodika
40
n3:tvurceVysledku
Sternberg, J. M. Schwarz, Alexandra Medrano-Mercado, N. Billingsley, P. F. Schaub, G. A.
n3:wos
000280936100008
n3:zamer
n11:AV0Z60220518
s:issn
0020-7519
s:numberOfPages
8