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Statements

Subject Item
n2:RIV%2F60077344%3A_____%2F10%3A00347271%21RIV11-GA0-60077344
rdf:type
skos:Concept n14:Vysledek
dcterms:description
Precise timing is essential for animal development. Its alteration, known as heterochrony, causes morphogenetic defects. Yet, little is known about the relationship between timing regulation and execution in terms of molecular action in the cell. Nuclear receptors play multiple roles in animal development, and NHR-25, an ancient member of the family, is involved in morphogenesis of various tissues of the worm C. elegans. We demonstrated that NHR-25 genetically interacts with the pathway of heterochronic genes including downstream targets of the let-7 microRNAs. NHR-25 together with the heterochronic genes modulates the timing of tissue-specific gene expression, cell fusion, cell division and cuticle formation. These data present the first example of a nuclear receptor interaction with the heterochrony pathway. Precise timing is essential for animal development. Its alteration, known as heterochrony, causes morphogenetic defects. Yet, little is known about the relationship between timing regulation and execution in terms of molecular action in the cell. Nuclear receptors play multiple roles in animal development, and NHR-25, an ancient member of the family, is involved in morphogenesis of various tissues of the worm C. elegans. We demonstrated that NHR-25 genetically interacts with the pathway of heterochronic genes including downstream targets of the let-7 microRNAs. NHR-25 together with the heterochronic genes modulates the timing of tissue-specific gene expression, cell fusion, cell division and cuticle formation. These data present the first example of a nuclear receptor interaction with the heterochrony pathway.
dcterms:title
The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition
skos:prefLabel
The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition
skos:notation
RIV/60077344:_____/10:00347271!RIV11-GA0-60077344
n3:aktivita
n8:Z n8:P
n3:aktivity
P(GA204/07/0948), P(GD204/09/H058), Z(AV0Z60220518)
n3:cisloPeriodika
2
n3:dodaniDat
n6:2011
n3:domaciTvurceVysledku
n15:2613034
n3:druhVysledku
n16:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
275556
n3:idVysledku
RIV/60077344:_____/10:00347271
n3:jazykVysledku
n9:eng
n3:klicovaSlova
apl-1; Caenorhabditis elegans; heterochronic gene; heterochronic gene; let-7; nuclear receptor; nhr-25
n3:klicoveSlovo
n10:Caenorhabditis%20elegans n10:let-7 n10:heterochronic%20gene n10:apl-1 n10:nhr-25 n10:nuclear%20receptor
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[6EEA35155D5D]
n3:nazevZdroje
Developmental Biology
n3:obor
n13:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:projekt
n12:GA204%2F07%2F0948 n12:GD204%2F09%2FH058
n3:rokUplatneniVysledku
n6:2010
n3:svazekPeriodika
344
n3:tvurceVysledku
Slack, F. J. Kanaho, Y. Niwa, R. Asahina, Masako Hasegawa, H. Hada, K.
n3:wos
000280787100049
n3:zamer
n7:AV0Z60220518
s:issn
0012-1606
s:numberOfPages
10