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Statements

Subject Item
n2:RIV%2F60077344%3A_____%2F10%3A00342884%21RIV11-GA0-60077344
rdf:type
skos:Concept n11:Vysledek
dcterms:description
Taking advantage of the different phenotypes between RNA interference knock-down cell lines in which the expression of proteins involved in mtRNA metabolism and editing can be silenced, we provide support for the view that ATP6 is encoded in the mt genome of Trypanosoma species and that it is incorporated into complex V. The reduction of the F1FO oligomer of complex V coincides with the accumulation of the F, moiety in ATP6-lacking cells, which also appear to lack the F-O ATP9 multimeric ring. The oligomycin sensitivity of ATPase activity of complex V in ATP6-lacking cells is reduced, reflecting the insensitivity of the Dk and Ak cells to this drug. In addition, the F, moiety of complex V appears to exist as a dimer in steady state conditions and contains the ATP4 subunit traditionally assigned to the F-O sub-complex. Taking advantage of the different phenotypes between RNA interference knock-down cell lines in which the expression of proteins involved in mtRNA metabolism and editing can be silenced, we provide support for the view that ATP6 is encoded in the mt genome of Trypanosoma species and that it is incorporated into complex V. The reduction of the F1FO oligomer of complex V coincides with the accumulation of the F, moiety in ATP6-lacking cells, which also appear to lack the F-O ATP9 multimeric ring. The oligomycin sensitivity of ATPase activity of complex V in ATP6-lacking cells is reduced, reflecting the insensitivity of the Dk and Ak cells to this drug. In addition, the F, moiety of complex V appears to exist as a dimer in steady state conditions and contains the ATP4 subunit traditionally assigned to the F-O sub-complex.
dcterms:title
The assembly of F1FO-ATP synthase is disrupted upon interference of RNA editing in Trypanosoma brucei The assembly of F1FO-ATP synthase is disrupted upon interference of RNA editing in Trypanosoma brucei
skos:prefLabel
The assembly of F1FO-ATP synthase is disrupted upon interference of RNA editing in Trypanosoma brucei The assembly of F1FO-ATP synthase is disrupted upon interference of RNA editing in Trypanosoma brucei
skos:notation
RIV/60077344:_____/10:00342884!RIV11-GA0-60077344
n3:aktivita
n6:P n6:Z
n3:aktivity
P(GA204/06/1558), P(IAA500960705), P(LC07032), Z(AV0Z60220518), Z(MSM6007665801)
n3:cisloPeriodika
1
n3:dodaniDat
n8:2011
n3:domaciTvurceVysledku
Lai, De Hua n14:1369490 n14:6203280
n3:druhVysledku
n10:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
247864
n3:idVysledku
RIV/60077344:_____/10:00342884
n3:jazykVysledku
n17:eng
n3:klicovaSlova
RNA editing; ATP synthase; mitochondrion; Trypanosoma; respiratory complex; membrane potential
n3:klicoveSlovo
n15:RNA%20editing n15:Trypanosoma n15:mitochondrion n15:membrane%20potential n15:respiratory%20complex n15:ATP%20synthase
n3:kodStatuVydavatele
AU - Australské společenství
n3:kontrolniKodProRIV
[D24558B02098]
n3:nazevZdroje
International Journal for Parasitology
n3:obor
n18:EB
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
6
n3:projekt
n4:LC07032 n4:GA204%2F06%2F1558 n4:IAA500960705
n3:rokUplatneniVysledku
n8:2010
n3:svazekPeriodika
40
n3:tvurceVysledku
Hashimi, Hassan Benkovičová, V. Lukeš, Julius Čermáková, P. Lai, De Hua Horváth, A.
n3:wos
000274104300005
n3:zamer
n7:MSM6007665801 n7:AV0Z60220518
s:issn
0020-7519
s:numberOfPages
10