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Statements

Subject Item
n2:RIV%2F60077344%3A_____%2F09%3A00329667%21RIV10-AV0-60077344
rdf:type
skos:Concept n13:Vysledek
dcterms:description
We analyzed genome-wide DNA methylation patterns in an isogenic human mammary epithelial cell (HMEC) culture model of transformation. To acquire immortality and malignancy, the cultured finite lifespan HMEC must overcome two distinct proliferation barriers. Our analysis of HMEC transitioning from finite lifespan to malignantly transformed showed that aberrant DNA methylation changes occur in a stepwise fashion early in the transformation process. The first aberrant DNA methylation step coincides with overcoming stasis, and results in few to hundreds of changes, depending on how stasis was overcome. A second step coincides with immortalization and results in hundreds of additional DNA methylation changes regardless of the immortalization pathway. A majority of these DNA methylation changes are also found in malignant breast cancer cells. We analyzed genome-wide DNA methylation patterns in an isogenic human mammary epithelial cell (HMEC) culture model of transformation. To acquire immortality and malignancy, the cultured finite lifespan HMEC must overcome two distinct proliferation barriers. Our analysis of HMEC transitioning from finite lifespan to malignantly transformed showed that aberrant DNA methylation changes occur in a stepwise fashion early in the transformation process. The first aberrant DNA methylation step coincides with overcoming stasis, and results in few to hundreds of changes, depending on how stasis was overcome. A second step coincides with immortalization and results in hundreds of additional DNA methylation changes regardless of the immortalization pathway. A majority of these DNA methylation changes are also found in malignant breast cancer cells.
dcterms:title
Stepwise DNA Methylation Changes Are Linked to Escape from Defined Proliferation Barriers and Mammary Epithelial Cell Immortalization Stepwise DNA Methylation Changes Are Linked to Escape from Defined Proliferation Barriers and Mammary Epithelial Cell Immortalization
skos:prefLabel
Stepwise DNA Methylation Changes Are Linked to Escape from Defined Proliferation Barriers and Mammary Epithelial Cell Immortalization Stepwise DNA Methylation Changes Are Linked to Escape from Defined Proliferation Barriers and Mammary Epithelial Cell Immortalization
skos:notation
RIV/60077344:_____/09:00329667!RIV10-AV0-60077344
n3:aktivita
n8:Z
n3:aktivity
Z(AV0Z50510513)
n3:cisloPeriodika
12
n3:dodaniDat
n15:2010
n3:domaciTvurceVysledku
n7:8813728
n3:druhVysledku
n17:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
343808
n3:idVysledku
RIV/60077344:_____/09:00329667
n3:jazykVysledku
n14:eng
n3:klicovaSlova
Epigenetics; Breast Cancer; DNA methylation
n3:klicoveSlovo
n4:Breast%20Cancer n4:Epigenetics n4:DNA%20methylation
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[57B206349103]
n3:nazevZdroje
Cancer Research
n3:obor
n11:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n15:2009
n3:svazekPeriodika
69
n3:tvurceVysledku
Novák, Petr Futscher, B. W. Garbe, J. Sampfer, M. R. Jensen, T. J.
n3:wos
000267506400042
n3:zamer
n9:AV0Z50510513
s:issn
0008-5472
s:numberOfPages
8