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Statements

Subject Item
n2:RIV%2F60077344%3A_____%2F08%3A00321729%21RIV09-GA0-60077344
rdf:type
skos:Concept n15:Vysledek
dcterms:description
In this study, we attempted to improve immunogenicity of the GUS-based anti-E7 vaccines by increasing the steady-state level of fusion proteins. We fused deletion mutants of E7GGG and codon-optimized E7GGG with the 5'-terminus of GUS and unaltered E7GGG with the 3'-terminus of GUS. Furthermore, we mutated the initiation codon of the GUS gene in the E7GGG.GUS construct, as GUS alone was produced from this fusion gene. In this study, we attempted to improve immunogenicity of the GUS-based anti-E7 vaccines by increasing the steady-state level of fusion proteins. We fused deletion mutants of E7GGG and codon-optimized E7GGG with the 5'-terminus of GUS and unaltered E7GGG with the 3'-terminus of GUS. Furthermore, we mutated the initiation codon of the GUS gene in the E7GGG.GUS construct, as GUS alone was produced from this fusion gene. V této práci jsme se pokusili zlepšit imunogenitu na GUS založené anti-E7 vakcíny zvýšením rovnovážné koncentrace tohoto fúzního proteinu. S 5' koncem GUS jsme fuzovali deleční mutanty E7GGG a kodonově optimalizovaný E7GGG, s 5' koncem GUS pak nezměněný E7GGG. Dále jsme mutovali iniciační kodon genu GUS v konstruktu E7GGG.GUS, neboť produktem tohoto fúzního genu byl samotný protein GUS.
dcterms:title
Enhancement of T cell-mediated and humoral immunity of beta-glucuronidase-based DNA vaccines against HPV16 E7 oncoprotein Zvýšení T buňkami zprostředkované a humorální imunity proti onkoproteinu E7 z HPV DNA vakcínou založenou na beta-glucuronidáze Enhancement of T cell-mediated and humoral immunity of beta-glucuronidase-based DNA vaccines against HPV16 E7 oncoprotein
skos:prefLabel
Enhancement of T cell-mediated and humoral immunity of beta-glucuronidase-based DNA vaccines against HPV16 E7 oncoprotein Enhancement of T cell-mediated and humoral immunity of beta-glucuronidase-based DNA vaccines against HPV16 E7 oncoprotein Zvýšení T buňkami zprostředkované a humorální imunity proti onkoproteinu E7 z HPV DNA vakcínou založenou na beta-glucuronidáze
skos:notation
RIV/60077344:_____/08:00321729!RIV09-GA0-60077344
n3:aktivita
n4:P n4:Z
n3:aktivity
P(GA521/05/2092), P(GD310/05/H533), P(NR9246), Z(AV0Z50510513)
n3:cisloPeriodika
1
n3:dodaniDat
n6:2009
n3:domaciTvurceVysledku
n8:8199655
n3:druhVysledku
n17:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
366264
n3:idVysledku
RIV/60077344:_____/08:00321729
n3:jazykVysledku
n18:eng
n3:klicovaSlova
immunogenicity; anti-E7 vaccines
n3:klicoveSlovo
n13:immunogenicity n13:anti-E7%20vaccines
n3:kodStatuVydavatele
GR - Řecká republika
n3:kontrolniKodProRIV
[A2632AFE6146]
n3:nazevZdroje
International Journal of Oncology
n3:obor
n16:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:projekt
n14:GD310%2F05%2FH533 n14:GA521%2F05%2F2092 n14:NR9246
n3:rokUplatneniVysledku
n6:2008
n3:svazekPeriodika
33
n3:tvurceVysledku
Šmahel, M. Vlasák, Josef Ludvíková, V. Poláková, I. Pokorná, D. Dušková, M.
n3:wos
000257276200010
n3:zamer
n12:AV0Z50510513
s:issn
1019-6439
s:numberOfPages
10