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Statements

Subject Item
n2:RIV%2F60076658%3A12640%2F04%3A00005714%21RIV%2F2005%2FGA0%2F126405%2FN
rdf:type
skos:Concept n8:Vysledek
dcterms:description
This work introduces a new approach connecting vibrational spectroscopy with homology and energetic molecular modeling of proteins. Combination of both methods can compensate their disadvantages and result in realistic three-dimensional protein models. The approach is most powerful for membrane proteins or glycoproteins with high carbohydrate content where X-ray or NMR analysis is not always successful. Nevertheless, it can also serve as a tool of preliminary analysis of any protein with unknown structure. Power of the approach is demonstrated on human alpha(1)-acid glycoprotein. Its predicted structure published in [V. Kopecky Jr. et al., Biochem. Biophys. Res. Commun. 300 (2003), 41-46] is discussed in detail with respect to the approach and its general employment. This work introduces a new approach connecting vibrational spectroscopy with homology and energetic molecular modeling of proteins. Combination of both methods can compensate their disadvantages and result in realistic three-dimensional protein models. The approach is most powerful for membrane proteins or glycoproteins with high carbohydrate content where X-ray or NMR analysis is not always successful. Nevertheless, it can also serve as a tool of preliminary analysis of any protein with unknown structure. Power of the approach is demonstrated on human alpha(1)-acid glycoprotein. Its predicted structure published in [V. Kopecky Jr. et al., Biochem. Biophys. Res. Commun. 300 (2003), 41-46] is discussed in detail with respect to the approach and its general employment. Nové metody pro rychlý odhad struktur proteinu byly vyvíjeny a vysvětleny na příkladu lidského orosomukoidu
dcterms:title
Vibrational spectroscopy and computer modeling of proteins: solving structure of alpha(1)-acid glycoprotein Vibrační spektroskopie a počítačové modelování proteinu: řešení struktury alpha-1-kyselého glykoproteinu Vibrational spectroscopy and computer modeling of proteins: solving structure of alpha(1)-acid glycoprotein
skos:prefLabel
Vibrační spektroskopie a počítačové modelování proteinu: řešení struktury alpha-1-kyselého glykoproteinu Vibrational spectroscopy and computer modeling of proteins: solving structure of alpha(1)-acid glycoprotein Vibrational spectroscopy and computer modeling of proteins: solving structure of alpha(1)-acid glycoprotein
skos:notation
RIV/60076658:12640/04:00005714!RIV/2005/GA0/126405/N
n3:strany
323-330
n3:aktivita
n14:P
n3:aktivity
P(GP206/03/D082), P(LN00A141)
n3:cisloPeriodika
2
n3:dodaniDat
n5:2005
n3:domaciTvurceVysledku
n17:6326633
n3:druhVysledku
n15:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
592396
n3:idVysledku
RIV/60076658:12640/04:00005714
n3:jazykVysledku
n13:eng
n3:klicovaSlova
Raman spectroscopy;fourier transform infrared spectroscopy;molecular modeling;orosomucoid;binding site;thermal dynamics
n3:klicoveSlovo
n4:thermal%20dynamics n4:molecular%20modeling n4:orosomucoid n4:Raman%20spectroscopy n4:fourier%20transform%20infrared%20spectroscopy n4:binding%20site
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[104EA04F8D6C]
n3:nazevZdroje
Spectroscopy - An International Journal
n3:obor
n9:BO
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
4
n3:projekt
n10:GP206%2F03%2FD082 n10:LN00A141
n3:rokUplatneniVysledku
n5:2004
n3:svazekPeriodika
18
n3:tvurceVysledku
Kopecký, Vladimír Ettrich, Rudiger Horst Baumruk, Vladimír Hofbauerová, Kateřina
s:issn
0712-4813
s:numberOfPages
8
n12:organizacniJednotka
12640