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Statements

Subject Item
n2:RIV%2F60076658%3A12520%2F14%3A43886857%21RIV15-GA0-12520___
rdf:type
n3:Vysledek skos:Concept
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/S0048969714011486
dcterms:description
Atenolol is a highly prescribed anti-hypertensive pharmaceutical and a member of the group of beta-blockers. It has been detected at concentrations ranging from ng L-1 to low mu g L-1 in waste and surface waters. The present study aimed to assess the sub-lethal effects of atenolol on rainbow trout (Oncorhynchus mykiss) and to determine its tissue-specific bioconcentration. Juvenile rainbow trout were exposed for 21 and 42 days to three concentration levels of atenolol (1 mu g L-1 environmentally relevant concentration, 10 mu g L-1, and 1000 mu g L-1). The fish exposed to 1 mu g L-1 atenolol exhibited a higher lactate content in the blood plasma and a reduced haemoglobin content compared with the control. The results show that exposure to atenolol at concentrations greater than or equal to 10 mu g L-1 significantly reduces both the haematocrit value and the glucose concentration in the blood plasma. The activities of the studied antioxidant enzymes (catalase and superoxide dismutase) were not significantly affected by atenolol exposure, and only the highest tested concentration of atenolol significantly reduced the activity of glutathione reductase. The activities of selected CYP450 enzymes were not affected by atenolol exposure. The histological changes indicate that atenolol has an effect on the vascular system, as evidenced by the observed liver congestion and changes in the pericardium and myocardium. Atenolol was found to have a very low bioconcentration factor (the highest value found was 0.27). The bioconcentration levels followed the order liver } kidney } muscle. The concentration of atenolol in the blood plasma was below the limit of quantification (10 ng g(-1)). The bioconcentration factors and the activities of selected CYP450 enzymes suggest that atenolol is not metabolised in the liver and may be excreted unchanged. Atenolol is a highly prescribed anti-hypertensive pharmaceutical and a member of the group of beta-blockers. It has been detected at concentrations ranging from ng L-1 to low mu g L-1 in waste and surface waters. The present study aimed to assess the sub-lethal effects of atenolol on rainbow trout (Oncorhynchus mykiss) and to determine its tissue-specific bioconcentration. Juvenile rainbow trout were exposed for 21 and 42 days to three concentration levels of atenolol (1 mu g L-1 environmentally relevant concentration, 10 mu g L-1, and 1000 mu g L-1). The fish exposed to 1 mu g L-1 atenolol exhibited a higher lactate content in the blood plasma and a reduced haemoglobin content compared with the control. The results show that exposure to atenolol at concentrations greater than or equal to 10 mu g L-1 significantly reduces both the haematocrit value and the glucose concentration in the blood plasma. The activities of the studied antioxidant enzymes (catalase and superoxide dismutase) were not significantly affected by atenolol exposure, and only the highest tested concentration of atenolol significantly reduced the activity of glutathione reductase. The activities of selected CYP450 enzymes were not affected by atenolol exposure. The histological changes indicate that atenolol has an effect on the vascular system, as evidenced by the observed liver congestion and changes in the pericardium and myocardium. Atenolol was found to have a very low bioconcentration factor (the highest value found was 0.27). The bioconcentration levels followed the order liver } kidney } muscle. The concentration of atenolol in the blood plasma was below the limit of quantification (10 ng g(-1)). The bioconcentration factors and the activities of selected CYP450 enzymes suggest that atenolol is not metabolised in the liver and may be excreted unchanged.
dcterms:title
The sub-lethal effects and tissue concentration of the human pharmaceutical atenolol in rainbow trout (Oncorhynchus mykiss) The sub-lethal effects and tissue concentration of the human pharmaceutical atenolol in rainbow trout (Oncorhynchus mykiss)
skos:prefLabel
The sub-lethal effects and tissue concentration of the human pharmaceutical atenolol in rainbow trout (Oncorhynchus mykiss) The sub-lethal effects and tissue concentration of the human pharmaceutical atenolol in rainbow trout (Oncorhynchus mykiss)
skos:notation
RIV/60076658:12520/14:43886857!RIV15-GA0-12520___
n4:aktivita
n18:S n18:P
n4:aktivity
P(ED2.1.00/01.0024), P(GAP503/11/1130), P(LO1205), S
n4:cisloPeriodika
Neuveden
n4:dodaniDat
n13:2015
n4:domaciTvurceVysledku
n6:6738699 n6:3929809 n6:9855130 Fedorova, Ganna n6:3414329 n6:5063949 n6:2927527 Steinbach, Christoph Antonius n6:9002375
n4:druhVysledku
n19:J
n4:duvernostUdaju
n8:S
n4:entitaPredkladatele
n20:predkladatel
n4:idSjednocenehoVysledku
48450
n4:idVysledku
RIV/60076658:12520/14:43886857
n4:jazykVysledku
n14:eng
n4:klicovaSlova
Histopathological changes; Haematological parameters; Bioconcentration; Biochemical markers; beta-Blockers; Antioxidant enzymes
n4:klicoveSlovo
n11:Antioxidant%20enzymes n11:Biochemical%20markers n11:Histopathological%20changes n11:beta-Blockers n11:Bioconcentration n11:Haematological%20parameters
n4:kodStatuVydavatele
NL - Nizozemsko
n4:kontrolniKodProRIV
[F622B1F5275C]
n4:nazevZdroje
Science of the Total Environment
n4:obor
n12:CE
n4:pocetDomacichTvurcuVysledku
9
n4:pocetTvurcuVysledku
10
n4:projekt
n5:LO1205 n5:ED2.1.00%2F01.0024 n5:GAP503%2F11%2F1130
n4:rokUplatneniVysledku
n13:2014
n4:svazekPeriodika
497
n4:tvurceVysledku
Kroupová, Hana Žlábek, Vladimír Burkina, Viktoriia Stará, Alžběta Schmidt-Posthaus, Heike Grabicová, Kateřina Grabic, Roman Steinbach, Christoph Antonius Velíšek, Josef Fedorova, Ganna
n4:wos
000343613100023
s:issn
0048-9697
s:numberOfPages
10
n17:doi
10.1016/j.scitotenv.2014.07.111
n16:organizacniJednotka
12520