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Statements

Subject Item
n2:RIV%2F60076658%3A12520%2F14%3A43886816%21RIV15-MSM-12520___
rdf:type
n8:Vysledek skos:Concept
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/S1532045614000106
dcterms:description
Cadmium is a heavy metal abundant in the environment that can induce endocrine disorder and toxicity in aquatic organisms at low levels. However, its effects on the thyroid system in fish are still unclear. In this study, the thyroid hormone (TH) levels and the expression profiles of genes related to hypothalamic-pituitary-thyroid (HPT) axis, including corticotropin-releasing hormone (crh), thyroid stimulating hormone beta (tsh beta), solute carrier family 5 (sodium iodide symporter) member 5 (slc5a5), thyroglobulin (tg), thyroid hormone receptor alpha (tr alpha) and thyroid hormone receptor beta (tr beta), were determined in whole body of Chinese rare minnow (Gobiogpris rams) larvae after exposure to different levels of Cd2+ (0, 0.5 and 2.5 mg/L) for 4 days. And the 96-h lethal concentration of Cd2+ on rare minnow larvae was determined as 2.59 mg/L. The results showed that crh, slc5a5, tg and tsh beta mRNA levels were significantly up-regulated in the larvae, but the gene expression of tr alpha and tr beta was down-regulated in a concentration-dependent manner. Besides, the This levels decreased in the whole-body of fish, especially the thyroxine (T4) level. The above results indicated that Cd2+ could alter gene expression in the HPT axis that might subsequently contribute to thyroid disruption. Cadmium is a heavy metal abundant in the environment that can induce endocrine disorder and toxicity in aquatic organisms at low levels. However, its effects on the thyroid system in fish are still unclear. In this study, the thyroid hormone (TH) levels and the expression profiles of genes related to hypothalamic-pituitary-thyroid (HPT) axis, including corticotropin-releasing hormone (crh), thyroid stimulating hormone beta (tsh beta), solute carrier family 5 (sodium iodide symporter) member 5 (slc5a5), thyroglobulin (tg), thyroid hormone receptor alpha (tr alpha) and thyroid hormone receptor beta (tr beta), were determined in whole body of Chinese rare minnow (Gobiogpris rams) larvae after exposure to different levels of Cd2+ (0, 0.5 and 2.5 mg/L) for 4 days. And the 96-h lethal concentration of Cd2+ on rare minnow larvae was determined as 2.59 mg/L. The results showed that crh, slc5a5, tg and tsh beta mRNA levels were significantly up-regulated in the larvae, but the gene expression of tr alpha and tr beta was down-regulated in a concentration-dependent manner. Besides, the This levels decreased in the whole-body of fish, especially the thyroxine (T4) level. The above results indicated that Cd2+ could alter gene expression in the HPT axis that might subsequently contribute to thyroid disruption.
dcterms:title
Effects of waterborne cadmium on thyroid hormone levels and related gene expression in Chinese rare minnow larvae Effects of waterborne cadmium on thyroid hormone levels and related gene expression in Chinese rare minnow larvae
skos:prefLabel
Effects of waterborne cadmium on thyroid hormone levels and related gene expression in Chinese rare minnow larvae Effects of waterborne cadmium on thyroid hormone levels and related gene expression in Chinese rare minnow larvae
skos:notation
RIV/60076658:12520/14:43886816!RIV15-MSM-12520___
n3:aktivita
n15:P
n3:aktivity
P(ED2.1.00/01.0024), P(LO1205)
n3:cisloPeriodika
April
n3:dodaniDat
n7:2015
n3:domaciTvurceVysledku
Li, Zhihua Li, Ping
n3:druhVysledku
n16:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
13801
n3:idVysledku
RIV/60076658:12520/14:43886816
n3:jazykVysledku
n19:eng
n3:klicovaSlova
Gene expression; Hypothalamic-pituitary-thyroid axis; Thyroid hormone; Chinese rare minnow; Cadmium
n3:klicoveSlovo
n4:Hypothalamic-pituitary-thyroid%20axis n4:Chinese%20rare%20minnow n4:Gene%20expression n4:Thyroid%20hormone n4:Cadmium
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[55E09C41AAAA]
n3:nazevZdroje
Comparative Biochemistry and Physiology C - Toxicology and Pharmacology
n3:obor
n17:GL
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
6
n3:projekt
n9:ED2.1.00%2F01.0024 n9:LO1205
n3:rokUplatneniVysledku
n7:2014
n3:svazekPeriodika
161
n3:tvurceVysledku
Chen, Lu Wu, Yan-Hua Ni, Zhao-Hui Li, Yun-Feng Li, Zhihua Li, Ping
n3:wos
000333792400008
s:issn
1532-0456
s:numberOfPages
5
n12:doi
10.1016/j.cbpc.2014.02.001
n13:organizacniJednotka
12520