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Statements

Subject Item
n2:RIV%2F60076658%3A12520%2F13%3A43885191%21RIV14-MZE-12520___
rdf:type
skos:Concept n13:Vysledek
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/S0048969713005457
dcterms:description
Verapamil is a pharmaceutical that belongs to a group of calcium channel blockers and is mainly used as a treatment of angina pectoris and arterial hypertension. Verapamil has been detected in aquatic environments in concentrations ranging from ngL(-1) to mu g L-1. In the present study, a series of acute toxicity tests of verapamil on various developmental stages of common carp (Cyprinus carpio) were conducted. As a result, 96hLC(50) values of verapamil were estimated at 16.4 +/- 92, 73 +/- 1.5 and 4.8 +/- 02 mg L-1 for embryos (E5-E9) and common carp larvae 12 and L5, respectively. Lethal concentrations of verapamil decreased with an increase in the age of the fish. Acute exposure to verapamil significantly reduced the heart rate in the embryos and larvae. In an embryo-larval toxicity test (sub-chronic exposure), the bioconcentration, depuration, and toxic effects of verapamil were assessed in common carp. The fish were exposed to verapamil in a concentration of 0.463 (environmentally relevant), 4.63, 463 and 463 mu g L-1. Verapamil had no effect on the accumulated mortality, hatching, condition factor, growth or ontogeny of the fish in any of the tested concentrations. In carp exposed to 463 and 46.3 mu g L-1 of verapamil, significantly higher occurrences of malformations and edemas were observed compared to the control. The bioconcentration factor of verapamil in whole fish homogenates ranged between 6.6 and 16.6 and was therefore below the critical value for hazard substances (BCF } 500). The half-life and the 95% depuration time for the tested compound were estimated to be 10.2 +/- 1.6 days and 44.2 +/- 8.6 days, respectively. No effects of verapamil on the studied endpoints were observed at environmentally relevant concentrations. Verapamil is a pharmaceutical that belongs to a group of calcium channel blockers and is mainly used as a treatment of angina pectoris and arterial hypertension. Verapamil has been detected in aquatic environments in concentrations ranging from ngL(-1) to mu g L-1. In the present study, a series of acute toxicity tests of verapamil on various developmental stages of common carp (Cyprinus carpio) were conducted. As a result, 96hLC(50) values of verapamil were estimated at 16.4 +/- 92, 73 +/- 1.5 and 4.8 +/- 02 mg L-1 for embryos (E5-E9) and common carp larvae 12 and L5, respectively. Lethal concentrations of verapamil decreased with an increase in the age of the fish. Acute exposure to verapamil significantly reduced the heart rate in the embryos and larvae. In an embryo-larval toxicity test (sub-chronic exposure), the bioconcentration, depuration, and toxic effects of verapamil were assessed in common carp. The fish were exposed to verapamil in a concentration of 0.463 (environmentally relevant), 4.63, 463 and 463 mu g L-1. Verapamil had no effect on the accumulated mortality, hatching, condition factor, growth or ontogeny of the fish in any of the tested concentrations. In carp exposed to 463 and 46.3 mu g L-1 of verapamil, significantly higher occurrences of malformations and edemas were observed compared to the control. The bioconcentration factor of verapamil in whole fish homogenates ranged between 6.6 and 16.6 and was therefore below the critical value for hazard substances (BCF } 500). The half-life and the 95% depuration time for the tested compound were estimated to be 10.2 +/- 1.6 days and 44.2 +/- 8.6 days, respectively. No effects of verapamil on the studied endpoints were observed at environmentally relevant concentrations.
dcterms:title
Toxic effects, bioconcentration and depuration of verapamil in the early life stages of common carp (Cyprinus carpio L.) Toxic effects, bioconcentration and depuration of verapamil in the early life stages of common carp (Cyprinus carpio L.)
skos:prefLabel
Toxic effects, bioconcentration and depuration of verapamil in the early life stages of common carp (Cyprinus carpio L.) Toxic effects, bioconcentration and depuration of verapamil in the early life stages of common carp (Cyprinus carpio L.)
skos:notation
RIV/60076658:12520/13:43885191!RIV14-MZE-12520___
n13:predkladatel
n14:orjk%3A12520
n3:aktivita
n17:I n17:S n17:P
n3:aktivity
I, P(ED2.1.00/01.0024), P(GAP503/11/1130), P(QH82117), S
n3:cisloPeriodika
Neuveden
n3:dodaniDat
n15:2014
n3:domaciTvurceVysledku
n4:3929809 Steinbach, Christoph Antonius n4:6738699 n4:5783593 n4:9548203 Fedorova, Ganna n4:9002375
n3:druhVysledku
n16:J
n3:duvernostUdaju
n20:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
111410
n3:idVysledku
RIV/60076658:12520/13:43885191
n3:jazykVysledku
n11:eng
n3:klicovaSlova
Verapamil; Heart rate; Half-life time; Embryo-larval test; Bioconcentration
n3:klicoveSlovo
n6:Embryo-larval%20test n6:Verapamil n6:Bioconcentration n6:Half-life%20time n6:Heart%20rate
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[599C7896E4C9]
n3:nazevZdroje
Science of the Total Environment
n3:obor
n21:GL
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
8
n3:projekt
n10:ED2.1.00%2F01.0024 n10:QH82117 n10:GAP503%2F11%2F1130
n3:rokUplatneniVysledku
n15:2013
n3:svazekPeriodika
461
n3:tvurceVysledku
Prokes, Miroslav Grabic, Roman Valentová, Olga Steinbach, Christoph Antonius Fedorova, Ganna Grabicová, Kateřina Kroupová, Hana Máchová, Jana
n3:wos
000323851500022
s:issn
0048-9697
s:numberOfPages
9
n18:doi
10.1016/j.scitotenv.2013.05.002
n7:organizacniJednotka
12520