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Statements

Subject Item
n2:RIV%2F60076658%3A12520%2F12%3A43883450%21RIV13-GA0-12520___
rdf:type
skos:Concept n8:Vysledek
dcterms:description
Adverse effects of bisphenol A (BPA) on reproductive physiology were studied in male goldfish (Carassius auratus) exposed to nominal environmentally relevant concentrations (0.2 and 20?mu g/L) for up to 90 d. Transcriptions of various reproductive genes were measured in brain, liver, and testis to investigate the BPA modes of action. Volume, density, total number, motility, and velocity of sperm were measured to assess testicular function. At 0.2?mu g/L, BPA reduced steroidogenetic acute regulatory protein and increased estrogen receptors (ERs) messenger RNA (mRNA) transcript (ER beta 1 in liver and ER beta 2 in testis) after 90 d. At 20?mu g/L, BPA increased mRNA transcript of androgen receptor in testis, brain- and testis-specific aromatase, and vitellogenin in liver after 90, 30, 60, and 60 d, respectively. Transcripts of ERs mRNA were increased after 30 to 60 d at 20?mu g/L BPA; increase in ER beta 1 mRNA was observed in testis after 7 d. Total number, volume, and motility of sperm were decreased in males exposed to 0.2 and 20?mu g/L BPA, whereas sperm density and velocity were only reduced at 20?mu g/L BPA. The results support the hypothesis that BPA may exert both anti-androgenic and estrogenic effects, depending on concentration, leading to diminished sperm quality. The findings provide a framework for better understanding of the mechanisms mediating adverse reproductive actions of BPA observed in different parts of the world. Adverse effects of bisphenol A (BPA) on reproductive physiology were studied in male goldfish (Carassius auratus) exposed to nominal environmentally relevant concentrations (0.2 and 20?mu g/L) for up to 90 d. Transcriptions of various reproductive genes were measured in brain, liver, and testis to investigate the BPA modes of action. Volume, density, total number, motility, and velocity of sperm were measured to assess testicular function. At 0.2?mu g/L, BPA reduced steroidogenetic acute regulatory protein and increased estrogen receptors (ERs) messenger RNA (mRNA) transcript (ER beta 1 in liver and ER beta 2 in testis) after 90 d. At 20?mu g/L, BPA increased mRNA transcript of androgen receptor in testis, brain- and testis-specific aromatase, and vitellogenin in liver after 90, 30, 60, and 60 d, respectively. Transcripts of ERs mRNA were increased after 30 to 60 d at 20?mu g/L BPA; increase in ER beta 1 mRNA was observed in testis after 7 d. Total number, volume, and motility of sperm were decreased in males exposed to 0.2 and 20?mu g/L BPA, whereas sperm density and velocity were only reduced at 20?mu g/L BPA. The results support the hypothesis that BPA may exert both anti-androgenic and estrogenic effects, depending on concentration, leading to diminished sperm quality. The findings provide a framework for better understanding of the mechanisms mediating adverse reproductive actions of BPA observed in different parts of the world.
dcterms:title
Modulations in androgen and estrogen mediating genes and testicular response in male goldfish exposed to bisphenol A Modulations in androgen and estrogen mediating genes and testicular response in male goldfish exposed to bisphenol A
skos:prefLabel
Modulations in androgen and estrogen mediating genes and testicular response in male goldfish exposed to bisphenol A Modulations in androgen and estrogen mediating genes and testicular response in male goldfish exposed to bisphenol A
skos:notation
RIV/60076658:12520/12:43883450!RIV13-GA0-12520___
n8:predkladatel
n9:orjk%3A12520
n3:aktivita
n16:S n16:P
n3:aktivity
P(ED2.1.00/01.0024), P(GA523/09/1793), P(GAP503/12/1834), S
n3:cisloPeriodika
9
n3:dodaniDat
n15:2013
n3:domaciTvurceVysledku
Hatef, Azadeh n11:6919707 n11:1593579
n3:druhVysledku
n13:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
151485
n3:idVysledku
RIV/60076658:12520/12:43883450
n3:jazykVysledku
n18:eng
n3:klicovaSlova
Vitellogenin; Steroidogenic acute regulatory protein; Sperm; Sex steroid receptor; P450 aromatase
n3:klicoveSlovo
n6:Sex%20steroid%20receptor n6:Sperm n6:Steroidogenic%20acute%20regulatory%20protein n6:P450%20aromatase n6:Vitellogenin
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[02909A3CF8DB]
n3:nazevZdroje
Environmental toxicology and chemistry
n3:obor
n5:GL
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
5
n3:projekt
n4:ED2.1.00%2F01.0024 n4:GA523%2F09%2F1793 n4:GAP503%2F12%2F1834
n3:rokUplatneniVysledku
n15:2012
n3:svazekPeriodika
31
n3:tvurceVysledku
Hatef, Azadeh Zare, A. Alavi, Sayyed Mohammad Hadi Habibi, H. R. Linhart, Otomar
n3:wos
000307938500020
s:issn
0730-7268
s:numberOfPages
9
n20:doi
10.1002/etc.1919
n17:organizacniJednotka
12520