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Statements

Subject Item
n2:RIV%2F60076658%3A12520%2F12%3A43883405%21RIV13-GA0-12520___
rdf:type
skos:Concept n13:Vysledek
dcterms:description
In mammals, vinclozolin (VZ) is known as anti-androgen, which causes male infertility via androgen receptor (AR) antagonism. In aquatic animals, the VZ effects on reproductive functions are largely unknown and results are somewhat contradictory. To understand VZ adverse effects on male reproduction, mature goldfish (Carassius auratus) were exposed to three nominal VZ concentrations (100, 400, and 800 mu g/L) and alternations in gonadosomatic (GSI) and hepatosomatic indices (HSI), 17 beta-estradiol (E-2), 11-ketotestosterone (11-KT) and sperm quality were investigated compared to the solvent control. One group was exposed to E-2 (nominal concentration of 5 mu g/L), an estrogenic compound, as a negative control. Following one month exposure, GSI and HSI were unchanged in all VZ treated groups compared to solvent control. Sperm volume, motility and velocity were reduced in fish exposed to 800 mu g/L VZ. This was associated with the decrease in 11-KT level, suggesting direct VZ effects on testicular androgenesis and sperm functions. In goldfish exposed to 100 mu g/L VZ, 11-KT was increased but E-2 remained unchanged. This is, probably, the main reason for unchanged sperm quality at 100 mu g/L VZ. In goldfish exposed to E-2, GSI and 11-KT were decreased, E-2 was increased and no sperm was produced. The present study shows different dose-dependent VZ effects, which lead to impairment in sperm quality via disruption in steroidogenesis. In addition to VZ effects through competitive binding to AR, our data suggests potential effects of VZ by direct inhibition of 11-KT biosynthesis in fish as well as abnormalities in sperm morphology. In mammals, vinclozolin (VZ) is known as anti-androgen, which causes male infertility via androgen receptor (AR) antagonism. In aquatic animals, the VZ effects on reproductive functions are largely unknown and results are somewhat contradictory. To understand VZ adverse effects on male reproduction, mature goldfish (Carassius auratus) were exposed to three nominal VZ concentrations (100, 400, and 800 mu g/L) and alternations in gonadosomatic (GSI) and hepatosomatic indices (HSI), 17 beta-estradiol (E-2), 11-ketotestosterone (11-KT) and sperm quality were investigated compared to the solvent control. One group was exposed to E-2 (nominal concentration of 5 mu g/L), an estrogenic compound, as a negative control. Following one month exposure, GSI and HSI were unchanged in all VZ treated groups compared to solvent control. Sperm volume, motility and velocity were reduced in fish exposed to 800 mu g/L VZ. This was associated with the decrease in 11-KT level, suggesting direct VZ effects on testicular androgenesis and sperm functions. In goldfish exposed to 100 mu g/L VZ, 11-KT was increased but E-2 remained unchanged. This is, probably, the main reason for unchanged sperm quality at 100 mu g/L VZ. In goldfish exposed to E-2, GSI and 11-KT were decreased, E-2 was increased and no sperm was produced. The present study shows different dose-dependent VZ effects, which lead to impairment in sperm quality via disruption in steroidogenesis. In addition to VZ effects through competitive binding to AR, our data suggests potential effects of VZ by direct inhibition of 11-KT biosynthesis in fish as well as abnormalities in sperm morphology.
dcterms:title
Anti-androgen vinclozolin impairs sperm quality and steroidogenesis in goldfish Anti-androgen vinclozolin impairs sperm quality and steroidogenesis in goldfish
skos:prefLabel
Anti-androgen vinclozolin impairs sperm quality and steroidogenesis in goldfish Anti-androgen vinclozolin impairs sperm quality and steroidogenesis in goldfish
skos:notation
RIV/60076658:12520/12:43883405!RIV13-GA0-12520___
n13:predkladatel
n14:orjk%3A12520
n3:aktivita
n7:S n7:P
n3:aktivity
P(ED2.1.00/01.0024), P(GA523/09/1793), S
n3:cisloPeriodika
08
n3:dodaniDat
n15:2013
n3:domaciTvurceVysledku
n17:6919707 n17:1593579 n17:6656269 Hatef, Azadeh n17:5033438
n3:druhVysledku
n11:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n20:predkladatel
n3:idSjednocenehoVysledku
122878
n3:idVysledku
RIV/60076658:12520/12:43883405
n3:jazykVysledku
n10:eng
n3:klicovaSlova
Vinclozolin; Sperm volume; Sperm velocity; Sperm motility; 17 beta-Estradiol; 11-ketotestosterone
n3:klicoveSlovo
n5:Vinclozolin n5:Sperm%20velocity n5:Sperm%20volume n5:11-ketotestosterone n5:Sperm%20motility n5:17%20beta-Estradiol
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[E0D8F2C23FEE]
n3:nazevZdroje
Aquatic Toxicology
n3:obor
n18:GL
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
7
n3:projekt
n4:ED2.1.00%2F01.0024 n4:GA523%2F09%2F1793
n3:rokUplatneniVysledku
n15:2012
n3:svazekPeriodika
122
n3:tvurceVysledku
Golshan, Mahdi Křišťan, Jiří Alavi, Sayyed Mohammad Hadi Fontaine, P. Hatef, Azadeh Linhart, Otomar Milla, S.
n3:wos
000308972000021
s:issn
0166-445X
s:numberOfPages
7
n9:doi
10.1016/j.aquatox.2012.06.009
n6:organizacniJednotka
12520