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Statements

Subject Item
n2:RIV%2F60076658%3A12520%2F11%3A43880513%21RIV12-MZP-12520___
rdf:type
skos:Concept n14:Vysledek
dcterms:description
Awareness of residual pharmaceutically active compounds (PhACs) in the aquatic environment is growing as investigations into these pollutants are increasing and analytical detection techniques are improving. In this study, the toxic effects of carbamazepine (CBZ), ananticonvulsant drug commonly present in surface and groundwater, was studied in juvenile rainbow trout, Oncorhynchus mykiss, by acute semi-static bioassay. Blood parameters, liver xenobiotic-metabolizing response and tissue antioxidant status were evaluated. Compared to the control group, fish exposed to CBZ (96hLC50) showed significantly higher Er, Hb, MCHC, monocytes, neutrophil granulocytes and plasma enzymes activity, and significantly lower MCV and lymphocytes. CF and HSI were not significantly different among groups such as hepatic EROD. SOD, CAT, GPx and GR activity was significantly higher in liver of experimental groups,but decreased significantly in brain and gill. Awareness of residual pharmaceutically active compounds (PhACs) in the aquatic environment is growing as investigations into these pollutants are increasing and analytical detection techniques are improving. In this study, the toxic effects of carbamazepine (CBZ), ananticonvulsant drug commonly present in surface and groundwater, was studied in juvenile rainbow trout, Oncorhynchus mykiss, by acute semi-static bioassay. Blood parameters, liver xenobiotic-metabolizing response and tissue antioxidant status were evaluated. Compared to the control group, fish exposed to CBZ (96hLC50) showed significantly higher Er, Hb, MCHC, monocytes, neutrophil granulocytes and plasma enzymes activity, and significantly lower MCV and lymphocytes. CF and HSI were not significantly different among groups such as hepatic EROD. SOD, CAT, GPx and GR activity was significantly higher in liver of experimental groups,but decreased significantly in brain and gill.
dcterms:title
Acute toxicity of carbamazepine to juvenile rainbow trout (Oncorhynchus mykiss): Effects on antioxidant responses, hematological parameters and hepatic EROD Acute toxicity of carbamazepine to juvenile rainbow trout (Oncorhynchus mykiss): Effects on antioxidant responses, hematological parameters and hepatic EROD
skos:prefLabel
Acute toxicity of carbamazepine to juvenile rainbow trout (Oncorhynchus mykiss): Effects on antioxidant responses, hematological parameters and hepatic EROD Acute toxicity of carbamazepine to juvenile rainbow trout (Oncorhynchus mykiss): Effects on antioxidant responses, hematological parameters and hepatic EROD
skos:notation
RIV/60076658:12520/11:43880513!RIV12-MZP-12520___
n14:predkladatel
n15:orjk%3A12520
n4:aktivita
n9:S n9:P
n4:aktivity
P(ED2.1.00/01.0024), P(SP/2E7/229/07), S
n4:cisloPeriodika
3
n4:dodaniDat
n5:2012
n4:domaciTvurceVysledku
n8:7985096 Li, Zhihua n8:5783593 n8:5063949 n8:9855130 Li, Ping n8:9002375 n8:1421204
n4:druhVysledku
n6:J
n4:duvernostUdaju
n20:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
184540
n4:idVysledku
RIV/60076658:12520/11:43880513
n4:jazykVysledku
n17:eng
n4:klicovaSlova
Hepatic EROD; Blood indices; Oxidative stress biomarkers; Fish; Pharmaceutical residues
n4:klicoveSlovo
n10:Fish n10:Oxidative%20stress%20biomarkers n10:Pharmaceutical%20residues n10:Blood%20indices n10:Hepatic%20EROD
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[D45AF6C47E18]
n4:nazevZdroje
Ecotoxicology and Environmental Safety
n4:obor
n7:GL
n4:pocetDomacichTvurcuVysledku
8
n4:pocetTvurcuVysledku
8
n4:projekt
n13:SP%2F2E7%2F229%2F07 n13:ED2.1.00%2F01.0024
n4:rokUplatneniVysledku
n5:2011
n4:svazekPeriodika
74
n4:tvurceVysledku
Li, Zhihua Li, Ping Grabic, Roman Velíšek, Josef Kolářová, Jitka Máchová, Jana Žlábek, Vladimír Randák, Tomáš
n4:wos
000288226700016
s:issn
0147-6513
s:numberOfPages
9
n18:doi
10.1016/j.ecoenv.2010.09.008
n19:organizacniJednotka
12520